Systemic diphenidol reduces neuropathic allodynia and TNF-alpha overexpression in rats after chronic constriction injury

doi:10.1016/j.neulet.2013.07.030

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標題:	Systemic diphenidol reduces neuropathic allodynia and TNF-alpha overexpression in rats after chronic constriction injury
作者:	Chen, Yu-Wen Tzeng, Jann-Inn Liu, Kuo-Sheng Yu, Shu-Han Hung, Ching-Hsia Wang, Jhi-Joung
貢獻者:	資訊多媒體應用系藥學系
關鍵字:	Diphenidol Intraperitoneal Injection Mechanical Allodynia Tumor Necrosis Factor-Alpha Chronic Constriction Injury
日期:	2013-09
上傳時間:	2014-05-26 10:49:48 (UTC+8)
出版者:	Elsevier Ireland Ltd
摘要:	Diphenidol has been shown to block voltage-gated Na+ channels, which are associated with specific types of pain. Here, we evaluated the effects of diphenidol on chronic constriction injury (CCI)-evoked allodynia and expression of tumor necrosis factor-alpha (TNF-alpha). A peripheral nerve injury was elicited in rats by placing four loosely constrictive ligatures around the sciatic nerve. After intraperitoneal injection of diphenidol, rats were tested for evidence of mechanical allodynia prior to surgery, and on postoperative days 3,6, 7, 11, 13 and 14. We showed that CCI rats received diphenidol caused dose-dependent increases in mechanical withdrawal threshold. Both diphenidol 2 and 10 mu mol/kg groups, but not 0.4 mu mol/kg diphenidol, displayed lower TNF-alpha level in the sciatic nerve than the CCI group (P<0.05) on day 7 after CCI. Our results support the conclusion that systemic diphenidol produced a dose-related inhibition of mechanical allodynia following chronic constriction injury of the sciatic nerve. This antiallodynic effect is related to the decrease of TNF-a expression in the sciatic nerve of CCI rats. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
關聯:	Neuroscience Letters, v.552, pp.62-65
顯示於類別:	[多媒體與遊戲發展系] 期刊論文 [藥學系(所)] 期刊論文

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