Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27938
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    標題: Systemic diphenidol reduces neuropathic allodynia and TNF-alpha overexpression in rats after chronic constriction injury
    作者: Chen, Yu-Wen
    Tzeng, Jann-Inn
    Liu, Kuo-Sheng
    Yu, Shu-Han
    Hung, Ching-Hsia
    Wang, Jhi-Joung
    貢獻者: 資訊多媒體應用系
    藥學系
    關鍵字: Diphenidol
    Intraperitoneal Injection
    Mechanical Allodynia
    Tumor Necrosis Factor-Alpha
    Chronic Constriction Injury
    日期: 2013-09
    上傳時間: 2014-05-26 10:49:48 (UTC+8)
    出版者: Elsevier Ireland Ltd
    摘要: Diphenidol has been shown to block voltage-gated Na+ channels, which are associated with specific types of pain. Here, we evaluated the effects of diphenidol on chronic constriction injury (CCI)-evoked allodynia and expression of tumor necrosis factor-alpha (TNF-alpha). A peripheral nerve injury was elicited in rats by placing four loosely constrictive ligatures around the sciatic nerve. After intraperitoneal injection of diphenidol, rats were tested for evidence of mechanical allodynia prior to surgery, and on postoperative days 3,6, 7, 11, 13 and 14. We showed that CCI rats received diphenidol caused dose-dependent increases in mechanical withdrawal threshold. Both diphenidol 2 and 10 mu mol/kg groups, but not 0.4 mu mol/kg diphenidol, displayed lower TNF-alpha level in the sciatic nerve than the CCI group (P<0.05) on day 7 after CCI. Our results support the conclusion that systemic diphenidol produced a dose-related inhibition of mechanical allodynia following chronic constriction injury of the sciatic nerve. This antiallodynic effect is related to the decrease of TNF-a expression in the sciatic nerve of CCI rats. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
    關聯: Neuroscience Letters, v.552, pp.62-65
    显示于类别:[資訊多媒體應用系] 期刊論文
    [藥學系(所)] 期刊論文

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