Systemic diphenidol reduces neuropathic allodynia and TNF-alpha overexpression in rats after chronic constriction injury

doi:10.1016/j.neulet.2013.07.030

CNU IR > College of Smart Living > Dept. of Multimedia and Game Development > Periodical Articles > Item 310902800/27938

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27938

Title:	Systemic diphenidol reduces neuropathic allodynia and TNF-alpha overexpression in rats after chronic constriction injury
Authors:	Chen, Yu-Wen Tzeng, Jann-Inn Liu, Kuo-Sheng Yu, Shu-Han Hung, Ching-Hsia Wang, Jhi-Joung
Contributors:	資訊多媒體應用系藥學系
Keywords:	Diphenidol Intraperitoneal Injection Mechanical Allodynia Tumor Necrosis Factor-Alpha Chronic Constriction Injury
Date:	2013-09
Issue Date:	2014-05-26 10:49:48 (UTC+8)
Publisher:	Elsevier Ireland Ltd
Abstract:	Diphenidol has been shown to block voltage-gated Na+ channels, which are associated with specific types of pain. Here, we evaluated the effects of diphenidol on chronic constriction injury (CCI)-evoked allodynia and expression of tumor necrosis factor-alpha (TNF-alpha). A peripheral nerve injury was elicited in rats by placing four loosely constrictive ligatures around the sciatic nerve. After intraperitoneal injection of diphenidol, rats were tested for evidence of mechanical allodynia prior to surgery, and on postoperative days 3,6, 7, 11, 13 and 14. We showed that CCI rats received diphenidol caused dose-dependent increases in mechanical withdrawal threshold. Both diphenidol 2 and 10 mu mol/kg groups, but not 0.4 mu mol/kg diphenidol, displayed lower TNF-alpha level in the sciatic nerve than the CCI group (P<0.05) on day 7 after CCI. Our results support the conclusion that systemic diphenidol produced a dose-related inhibition of mechanical allodynia following chronic constriction injury of the sciatic nerve. This antiallodynic effect is related to the decrease of TNF-a expression in the sciatic nerve of CCI rats. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
Relation:	Neuroscience Letters, v.552, pp.62-65
Appears in Collections:	[Dept. of Multimedia and Game Development] Periodical Articles [Dept. of Pharmacy] Periodical Articles

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	1775	View/Open

Loading...