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| 標題: | Effects of statins on anxiety and depression in patients with asthma-chronic obstructive pulmonary disease overlap syndrome |
| 作者: | Yeh, Jun-Jun(葉俊濬)
Syue, Shih-Huei
Lin, Cheng-Li
Hsu, Chung Y.
Shae, Zonyin
Kao, Chia-Hung |
| 貢獻者: | Chia Yi Christian Hosp, Ditmanson Med Fdn
Chia Nan Univ Pharm & Sci
China Med Univ
Mei Ho Univ, Neipu Township
China Med Univ Hosp, Management Off Hlth Data
China Med Univ, Coll Med
China Med Univ, Coll Med, Grad Inst Biomed Sci
China Med Univ, Coll Med, Sch Med
Asia Univ, Dept Comp Sci & Informat Engn
China Med Univ Hosp, Dept Nucl Med
China Med Univ Hosp, PET Ctr
Asia Univ, Dept Bioinformat & Med Engn |
| 關鍵字: | Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS)
Statin inhaled corticosteroids (ICSs)
Oral steroids (OSs) |
| 日期: | 2019-06 |
| 上傳時間: | 2020-07-29 13:48:10 (UTC+8) |
| 出版者: | ELSEVIER SCIENCE BV |
| 摘要: | Background: The effects of statins on anxiety and depression in patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) have not been reported. This population-based study investigated these effects. Methods: Taiwan's National Health Insurance Research Database between 2000 and 2010. We enrolled two ACOS cohorts, one of statin users (n = 1252) and one of nonstatin users matched by age, sex, and index date (n = 7887). The cumulative incidence of anxiety and depression was analyzed using time-dependent Cox proportional regression analysis. Results: After adjustment for multiple confounding factors, including age, sex, comorbidities, and medications-statins, inhaled corticosteroids (ICSs), and oral steroids (OSs)-the ACOS cohort with statin use had significantly lower risks of anxiety and depression (anxiety: adjusted hazard ratio [aHR] = 0.34, 95% confidence interval [CI] = 0.28-0.42; depression: aHR = 0.36, 95% CI = 0.25-0.53). The aHRs (95% CIs) for statin use with ICSs or OSs were 0.32 (0.13-0.78) and 0.37 (0.24-0.57), respectively. Conclusion: The ACOS cohort with statin use had lower risks of anxiety and depression, regardless of age, sex, commodities, or ICSs and OSs. The incidences of anxiety and depression were relatively low among users of statins with ICSs or OSs in the ACOS cohort. |
| 關聯: | Journal of Affective Disorders, v.253, 277-284 |
| 顯示於類別: | [嬰幼兒保育系] 期刊論文
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