Effects of statins on anxiety and depression in patients with asthma-chronic obstructive pulmonary disease overlap syndrome

doi:10.1016/j.jad.2019.05.002

Chia Nan University of Pharmacy & Science Institutional Repository > 智慧生活學院 > 嬰幼兒保育系 > 期刊論文 > Item 310902800/32516

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標題:	Effects of statins on anxiety and depression in patients with asthma-chronic obstructive pulmonary disease overlap syndrome
作者:	Yeh, Jun-Jun(葉俊濬) Syue, Shih-Huei Lin, Cheng-Li Hsu, Chung Y. Shae, Zonyin Kao, Chia-Hung
貢獻者:	Chia Yi Christian Hosp, Ditmanson Med Fdn Chia Nan Univ Pharm & Sci China Med Univ Mei Ho Univ, Neipu Township China Med Univ Hosp, Management Off Hlth Data China Med Univ, Coll Med China Med Univ, Coll Med, Grad Inst Biomed Sci China Med Univ, Coll Med, Sch Med Asia Univ, Dept Comp Sci & Informat Engn China Med Univ Hosp, Dept Nucl Med China Med Univ Hosp, PET Ctr Asia Univ, Dept Bioinformat & Med Engn
關鍵字:	Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) Statin inhaled corticosteroids (ICSs) Oral steroids (OSs)
日期:	2019-06
上傳時間:	2020-07-29 13:48:10 (UTC+8)
出版者:	ELSEVIER SCIENCE BV
摘要:	Background: The effects of statins on anxiety and depression in patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) have not been reported. This population-based study investigated these effects. Methods: Taiwan's National Health Insurance Research Database between 2000 and 2010. We enrolled two ACOS cohorts, one of statin users (n = 1252) and one of nonstatin users matched by age, sex, and index date (n = 7887). The cumulative incidence of anxiety and depression was analyzed using time-dependent Cox proportional regression analysis. Results: After adjustment for multiple confounding factors, including age, sex, comorbidities, and medications-statins, inhaled corticosteroids (ICSs), and oral steroids (OSs)-the ACOS cohort with statin use had significantly lower risks of anxiety and depression (anxiety: adjusted hazard ratio [aHR] = 0.34, 95% confidence interval [CI] = 0.28-0.42; depression: aHR = 0.36, 95% CI = 0.25-0.53). The aHRs (95% CIs) for statin use with ICSs or OSs were 0.32 (0.13-0.78) and 0.37 (0.24-0.57), respectively. Conclusion: The ACOS cohort with statin use had lower risks of anxiety and depression, regardless of age, sex, commodities, or ICSs and OSs. The incidences of anxiety and depression were relatively low among users of statins with ICSs or OSs in the ACOS cohort.
關聯:	Journal of Affective Disorders, v.253, 277-284
显示于类别:	[嬰幼兒保育系] 期刊論文

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