Effects of statins on anxiety and depression in patients with asthma-chronic obstructive pulmonary disease overlap syndrome

doi:10.1016/j.jad.2019.05.002

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Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/32516

Title:	Effects of statins on anxiety and depression in patients with asthma-chronic obstructive pulmonary disease overlap syndrome
Authors:	Yeh, Jun-Jun(葉俊濬) Syue, Shih-Huei Lin, Cheng-Li Hsu, Chung Y. Shae, Zonyin Kao, Chia-Hung
Contributors:	Chia Yi Christian Hosp, Ditmanson Med Fdn Chia Nan Univ Pharm & Sci China Med Univ Mei Ho Univ, Neipu Township China Med Univ Hosp, Management Off Hlth Data China Med Univ, Coll Med China Med Univ, Coll Med, Grad Inst Biomed Sci China Med Univ, Coll Med, Sch Med Asia Univ, Dept Comp Sci & Informat Engn China Med Univ Hosp, Dept Nucl Med China Med Univ Hosp, PET Ctr Asia Univ, Dept Bioinformat & Med Engn
Keywords:	Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) Statin inhaled corticosteroids (ICSs) Oral steroids (OSs)
Date:	2019-06
Issue Date:	2020-07-29 13:48:10 (UTC+8)
Publisher:	ELSEVIER SCIENCE BV
Abstract:	Background: The effects of statins on anxiety and depression in patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) have not been reported. This population-based study investigated these effects. Methods: Taiwan's National Health Insurance Research Database between 2000 and 2010. We enrolled two ACOS cohorts, one of statin users (n = 1252) and one of nonstatin users matched by age, sex, and index date (n = 7887). The cumulative incidence of anxiety and depression was analyzed using time-dependent Cox proportional regression analysis. Results: After adjustment for multiple confounding factors, including age, sex, comorbidities, and medications-statins, inhaled corticosteroids (ICSs), and oral steroids (OSs)-the ACOS cohort with statin use had significantly lower risks of anxiety and depression (anxiety: adjusted hazard ratio [aHR] = 0.34, 95% confidence interval [CI] = 0.28-0.42; depression: aHR = 0.36, 95% CI = 0.25-0.53). The aHRs (95% CIs) for statin use with ICSs or OSs were 0.32 (0.13-0.78) and 0.37 (0.24-0.57), respectively. Conclusion: The ACOS cohort with statin use had lower risks of anxiety and depression, regardless of age, sex, commodities, or ICSs and OSs. The incidences of anxiety and depression were relatively low among users of statins with ICSs or OSs in the ACOS cohort.
Relation:	Journal of Affective Disorders, v.253, 277-284
Appears in Collections:	[Dept. of Childhood Education and Nursery] Periodical Articles

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