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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/24224


    標題: Synthetic and Cytotoxic Studies on Alkyl 4-(3,4,5-trimethoxyphenoxy) benzoate
    作者: Wen-Yueh Ho (何文岳)
    Chia-Hua Liang (梁家華)
    Jui-Hsiang Hung (洪瑞祥)
    Wen-Jong Vong (汪文忠)
    Po-Jui Huang (黃博瑞)
    Kuan-Han Lee (李冠漢)
    日期: 2011
    上傳時間: 2011-06-23 14:57:16 (UTC+8)
    摘要: Diaryl ethers represent an important class of synthetic compounds recognized as potential anticancer drugs. Experimental and pre-clinical models have demonstrated that a number of these compounds elicit outstanding anticancer activity through the significant inhibition of tubulin assembly accompanied by potent antiproliferative activity. Moreover, the diaryl ether scaffold is found in a number of natural products and biologically important molecules, such as vancomycin and piperazinomycin. As a result of our continuing studies aimed at the discovery and development of potential anticancer agents, herein we report the synthesis, cytotoxic activities of a series of nlovel diaryl ethers. Diaryl ether (1) was synthesized via Ullmann-type coupling. Palladium(II) acetate catalyzed O-arylation reactions have been carried out in non-polar solvent and used K3PO4 as the base. Saponification in ethanolic NaOH solution afforded the acid form (2). Both compound 1 and 2 were shown selective cytotoxic activity against A549 (Human lung adenocarcinoma epithelial cell line) with the IC50 values of 2.1 μM and 12.3 μM, respectively.
    關聯: 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會,起迄日:2011/04/06~2011/04/05,地點:溪頭台大實驗林
    Appears in Collections:[藥理學院] 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會
    [藥學系(所)] 會議論文
    [化妝品應用與管理系(所)] 會議論文
    [生物科技系(所)] 會議論文
    [醫藥化學系 ] 會議論文

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