Synthetic and Cytotoxic Studies on Alkyl 4-(3,4,5-trimethoxyphenoxy) benzoate

CNU IR > Pharmacy and Science > 2011 Taiwanese-Russian Organic, Medicinal and Bio Chemistry Interactions & PST Medicinal Chemistry Symposium > Item 310902800/24224

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/24224

Title:	Synthetic and Cytotoxic Studies on Alkyl 4-(3,4,5-trimethoxyphenoxy) benzoate
Authors:	Wen-Yueh Ho (何文岳) Chia-Hua Liang (梁家華) Jui-Hsiang Hung (洪瑞祥) Wen-Jong Vong (汪文忠) Po-Jui Huang (黃博瑞) Kuan-Han Lee (李冠漢)
Date:	2011
Issue Date:	2011-06-23 14:57:16 (UTC+8)
Abstract:	Diaryl ethers represent an important class of synthetic compounds recognized as potential anticancer drugs. Experimental and pre-clinical models have demonstrated that a number of these compounds elicit outstanding anticancer activity through the significant inhibition of tubulin assembly accompanied by potent antiproliferative activity. Moreover, the diaryl ether scaffold is found in a number of natural products and biologically important molecules, such as vancomycin and piperazinomycin. As a result of our continuing studies aimed at the discovery and development of potential anticancer agents, herein we report the synthesis, cytotoxic activities of a series of nlovel diaryl ethers. Diaryl ether (1) was synthesized via Ullmann-type coupling. Palladium(II) acetate catalyzed O-arylation reactions have been carried out in non-polar solvent and used K3PO4 as the base. Saponification in ethanolic NaOH solution afforded the acid form (2). Both compound 1 and 2 were shown selective cytotoxic activity against A549 (Human lung adenocarcinoma epithelial cell line) with the IC50 values of 2.1 μM and 12.3 μM, respectively.
Relation:	2011年台俄有機、藥物與生物化學交流暨藥物化學研討會，起迄日：2011/04/06~2011/04/05，地點：溪頭台大實驗林
Appears in Collections:	[Pharmacy and Science] 2011 Taiwanese-Russian Organic, Medicinal and Bio Chemistry Interactions & PST Medicinal Chemistry Symposium [Dept. of Pharmacy] Proceedings [Dept. of Cosmetic Science and institute of cosmetic science] Proceedings [Dept. of Biotechnology (including master's program)] Proceedings [Dept. of Food & Drug Industry and Inspective Technology] Proceedings

Files in This Item:

File	Description	Size	Format
pp-08.pdf		74Kb	Adobe PDF	623	View/Open

Loading...