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https://ir.cnu.edu.tw/handle/310902800/34898
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| 標題: | Distribution and clinical features of lymphomas involving skin in Taiwan |
| 作者: | Wu, Cheng-Lin
Chang, Su-Wei
Lee, Julia Yu-Yun
Chen, Tsai-Yun
Chen, Chien-Chin
Chu, Chia-Bao
Medeiros, L. Jeffrey
Chang, Kung-Chao |
| 貢獻者: | Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Pathol
Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Inst Clin Med, Coll Med
Chang Gung Univ, Clin Informat & Med Stat Res Ctr
Chang Gung Mem Hosp Linkou, Dept Lab Med
Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Dermatol
Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Internal Med
Chia Yi Christian Hosp, Dept Pathol
Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
Natl Cheng Kung Univ, Inst Basic Med Sci, Coll Med
Univ Texas MD Anderson Canc Ctr, Dept Hematopathol
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Coll Med, Dept Pathol
Kaohsiung Med Univ, Ctr Canc Res |
| 關鍵字: | clinicopathologic factors
cutaneous lymphoma
primary
prognosis
secondary |
| 日期: | 2023 |
| 上傳時間: | 2024-12-25 11:05:16 (UTC+8) |
| 出版者: | WILEY |
| 摘要: | A wide variety of primary and secondary lymphoma types involves the skin. However, reports with comparisons between both groups are limited in Taiwan. We retrospectively enrolled all cutaneous lymphomas and evaluated their clinicopathologic features. There were 221 cases of lymphoma: 182 (82.3%) primary and 39 (17.7%) secondary. Mycosis fungoides was the most common primary T-cell lymphoma, 92 (41.7%) cases, followed by CD30-positive T-cell lymphoproliferative disorders including lymphomatoid papulosis (n = 33, 14.9%) and cutaneous anaplastic large cell lymphoma (n = 12, 5.4%). The most frequent primary B-cell lymphomas were marginal zone lymphoma (n = 8, 3.6%) and diffuse large B-cell lymphoma (DLBCL), leg type (n = 8, 3.6%). DLBCL including variants was the most common secondary lymphoma involving skin. Most primary lymphomas presented at low-stage (T-cell, 86%; B-cell, 75%), whereas the majority of secondary lymphomas presented at high-stage (T-cell, 94%; B-cell, 100%). Patients with secondary lymphomas had an older mean age, more frequent B symptoms, lower serum albumin and hemoglobin, and a higher frequency of atypical lymphocytes in blood than those with primary lymphomas. In primary lymphomas, older age, lymphoma types, decreased lymphocyte counts and atypical lymphocytes in blood were poorer prognostic factors. In secondary lymphoma patients, lymphoma types, high serum lactate dehydrogenase and low hemoglobin levels predicted poorer survival. We found that the distribution of primary cutaneous lymphomas in Taiwan mirrors that of other Asian countries but shows some differences as compared with Western countries. Primary cutaneous lymphomas have a better prognosis than secondary lymphomas. Histologic classification of lymphomas highly correlated with disease presentation and prognosis. |
| 關聯: | Kaohsiung Journal of Medical Sciences, v.39, n.5, pp.522-532 |
| 顯示於類別: | [行政單位] 456
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