Distribution and clinical features of lymphomas involving skin in Taiwan

doi:10.1002/kjm2.12659

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/34898

Metadata null

Citation Infomation

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34898

Title:	Distribution and clinical features of lymphomas involving skin in Taiwan
Authors:	Wu, Cheng-Lin Chang, Su-Wei Lee, Julia Yu-Yun Chen, Tsai-Yun Chen, Chien-Chin Chu, Chia-Bao Medeiros, L. Jeffrey Chang, Kung-Chao
Contributors:	Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Pathol Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Inst Clin Med, Coll Med Chang Gung Univ, Clin Informat & Med Stat Res Ctr Chang Gung Mem Hosp Linkou, Dept Lab Med Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Dermatol Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Internal Med Chia Yi Christian Hosp, Dept Pathol Chia Nan Univ Pharm & Sci, Dept Cosmet Sci Natl Cheng Kung Univ, Inst Basic Med Sci, Coll Med Univ Texas MD Anderson Canc Ctr, Dept Hematopathol Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Coll Med, Dept Pathol Kaohsiung Med Univ, Ctr Canc Res
Keywords:	clinicopathologic factors cutaneous lymphoma primary prognosis secondary
Date:	2023
Issue Date:	2024-12-25 11:05:16 (UTC+8)
Publisher:	WILEY
Abstract:	A wide variety of primary and secondary lymphoma types involves the skin. However, reports with comparisons between both groups are limited in Taiwan. We retrospectively enrolled all cutaneous lymphomas and evaluated their clinicopathologic features. There were 221 cases of lymphoma: 182 (82.3%) primary and 39 (17.7%) secondary. Mycosis fungoides was the most common primary T-cell lymphoma, 92 (41.7%) cases, followed by CD30-positive T-cell lymphoproliferative disorders including lymphomatoid papulosis (n = 33, 14.9%) and cutaneous anaplastic large cell lymphoma (n = 12, 5.4%). The most frequent primary B-cell lymphomas were marginal zone lymphoma (n = 8, 3.6%) and diffuse large B-cell lymphoma (DLBCL), leg type (n = 8, 3.6%). DLBCL including variants was the most common secondary lymphoma involving skin. Most primary lymphomas presented at low-stage (T-cell, 86%; B-cell, 75%), whereas the majority of secondary lymphomas presented at high-stage (T-cell, 94%; B-cell, 100%). Patients with secondary lymphomas had an older mean age, more frequent B symptoms, lower serum albumin and hemoglobin, and a higher frequency of atypical lymphocytes in blood than those with primary lymphomas. In primary lymphomas, older age, lymphoma types, decreased lymphocyte counts and atypical lymphocytes in blood were poorer prognostic factors. In secondary lymphoma patients, lymphoma types, high serum lactate dehydrogenase and low hemoglobin levels predicted poorer survival. We found that the distribution of primary cutaneous lymphomas in Taiwan mirrors that of other Asian countries but shows some differences as compared with Western countries. Primary cutaneous lymphomas have a better prognosis than secondary lymphomas. Histologic classification of lymphomas highly correlated with disease presentation and prognosis.
Relation:	Kaohsiung Journal of Medical Sciences, v.39, n.5, pp.522-532
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	136	View/Open
kjm2.12659.pdf		2039Kb	Adobe PDF	34	View/Open

Loading...