Distribution and clinical features of lymphomas involving skin in Taiwan

doi:10.1002/kjm2.12659

Chia Nan University of Pharmacy & Science Institutional Repository > 行政單位 > 456 > Item 310902800/34898

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標題:	Distribution and clinical features of lymphomas involving skin in Taiwan
作者:	Wu, Cheng-Lin Chang, Su-Wei Lee, Julia Yu-Yun Chen, Tsai-Yun Chen, Chien-Chin Chu, Chia-Bao Medeiros, L. Jeffrey Chang, Kung-Chao
貢獻者:	Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Pathol Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Inst Clin Med, Coll Med Chang Gung Univ, Clin Informat & Med Stat Res Ctr Chang Gung Mem Hosp Linkou, Dept Lab Med Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Dermatol Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Internal Med Chia Yi Christian Hosp, Dept Pathol Chia Nan Univ Pharm & Sci, Dept Cosmet Sci Natl Cheng Kung Univ, Inst Basic Med Sci, Coll Med Univ Texas MD Anderson Canc Ctr, Dept Hematopathol Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Coll Med, Dept Pathol Kaohsiung Med Univ, Ctr Canc Res
關鍵字:	clinicopathologic factors cutaneous lymphoma primary prognosis secondary
日期:	2023
上傳時間:	2024-12-25 11:05:16 (UTC+8)
出版者:	WILEY
摘要:	A wide variety of primary and secondary lymphoma types involves the skin. However, reports with comparisons between both groups are limited in Taiwan. We retrospectively enrolled all cutaneous lymphomas and evaluated their clinicopathologic features. There were 221 cases of lymphoma: 182 (82.3%) primary and 39 (17.7%) secondary. Mycosis fungoides was the most common primary T-cell lymphoma, 92 (41.7%) cases, followed by CD30-positive T-cell lymphoproliferative disorders including lymphomatoid papulosis (n = 33, 14.9%) and cutaneous anaplastic large cell lymphoma (n = 12, 5.4%). The most frequent primary B-cell lymphomas were marginal zone lymphoma (n = 8, 3.6%) and diffuse large B-cell lymphoma (DLBCL), leg type (n = 8, 3.6%). DLBCL including variants was the most common secondary lymphoma involving skin. Most primary lymphomas presented at low-stage (T-cell, 86%; B-cell, 75%), whereas the majority of secondary lymphomas presented at high-stage (T-cell, 94%; B-cell, 100%). Patients with secondary lymphomas had an older mean age, more frequent B symptoms, lower serum albumin and hemoglobin, and a higher frequency of atypical lymphocytes in blood than those with primary lymphomas. In primary lymphomas, older age, lymphoma types, decreased lymphocyte counts and atypical lymphocytes in blood were poorer prognostic factors. In secondary lymphoma patients, lymphoma types, high serum lactate dehydrogenase and low hemoglobin levels predicted poorer survival. We found that the distribution of primary cutaneous lymphomas in Taiwan mirrors that of other Asian countries but shows some differences as compared with Western countries. Primary cutaneous lymphomas have a better prognosis than secondary lymphomas. Histologic classification of lymphomas highly correlated with disease presentation and prognosis.
關聯:	Kaohsiung Journal of Medical Sciences, v.39, n.5, pp.522-532
显示于类别:	[行政單位] 456

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