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| 標題: | Signal intensity coefficient as a detector of aortic stenosis-induced myocardial fibrosis and its correlation to the long term outcome |
| 作者: | Chang, Wei-Ting
Lin, Chih-Hsien
Lee, Wei-Chieh
Kan, Wei-Chih
Lin, You-Cheng
Hiremath, Pranoti
Cheng, Susan
Liao, Ronglih
Chen, Zhih-Cherng
Huang, Po-Sen
Wu, Nan-Chun |
| 貢獻者: | Natl Sun Yat Sen Univ, Sch Med
Natl Sun Yat Sen Univ, Coll Med, Doctoral Program Clin & Expt Med
Natl Sun Yat Sen Univ, Ctr Excellence Metab Associated Fatty Liver Dis
Chi Mei Med Ctr, Dept Internal Med, Div Cardiol
Natl Sun Yat Sen Univ, Coll Med, Sch Med
Chi Mei Med Ctr, Dept Internal Med, Div Nephrol
Chung Hwa Univ Med Technol, Dept Med Lab Sci & Biotechnol
Chi Mei Med Ctr, Dept Surg, Div Plast Surg
Johns Hopkins Univ Hosp
Cedars Sinai Med Ctr, Smidt Heart Inst, Dept Cardiol
Stanford Univ, Sch Med, Stanford Cardiovasc Inst
Harvard Med Sch, Brigham & Womens Hosp, Dept Med
Chi Mei Med Ctr, Dept Surg, Div Cardiovasc Surg
Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm |
| 關鍵字: | Signal intensity coefficient
Aortic stenosis
Cardiovascular death
Myocardial fibrosis |
| 日期: | 2024 |
| 上傳時間: | 2024-12-25 11:04:46 (UTC+8) |
| 出版者: | ELSEVIER IRELAND LTD |
| 摘要: | Objective: Despite advanced aortic valve replacement techniques, aortic stenosis (AS)-induced irreversible myocardial fibrosis contributes to poorer outcomes. Therefore, in addition to early diagnosis of AS, detecting myocardial fibrosis is crucial for physicians to determine the timing of surgery. The Signal Intensity Coefficient (SIC) was used to detect subtle myocardial deformation. Hence, we aimed to investigate whether SIC correlated with myocardial dysfunction and fibrosis from both clinical and preclinical perspectives.Methods: We collected medical records and echocardiography images, including the SIC of patients who underwent surgical aortic valve replacement (AVR) for AS from 2010 to 2015. The endpoint of the study was mortality. Median follow-up period was 80 months. Results: Among 109 patients, 15 died due to cardiovascular causes. Although SIC decreased in all patients postAVR, patients with an SIC >= 0.34 before surgeries presented with a higher probability of cardiovascular death. In contrast, changes in the left ventricular (LV) ejection fraction, LV mass index, and LV volume failed to predict outcomes. Similarly, SIC was obtained in mice undergoing aortic banding and debanding surgery for comparison with the degree of myocardial fibrosis. SIC was continuously elevated after aortic banding and declined gradually after debanding surgery in mice. Debanding surgery indicated the regression of aortic banding-induced myocardial fibrosis.Conclusion: Pre-AVR SIC was associated with the risk of cardiovascular death and reflected the degree of myocardial fibrosis. Further investigations are required to study the clinical application of SIC in patients with AS. |
| 關聯: | International Journal of Cardiology, v.394, Article 131367 |
| 顯示於類別: | [行政單位] 456
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