Signal intensity coefficient as a detector of aortic stenosis-induced myocardial fibrosis and its correlation to the long term outcome

doi:10.1016/j.ijcard.2023.131367

Chia Nan University of Pharmacy & Science Institutional Repository > 行政單位 > 456 > Item 310902800/34864

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/34864

標題:	Signal intensity coefficient as a detector of aortic stenosis-induced myocardial fibrosis and its correlation to the long term outcome
作者:	Chang, Wei-Ting Lin, Chih-Hsien Lee, Wei-Chieh Kan, Wei-Chih Lin, You-Cheng Hiremath, Pranoti Cheng, Susan Liao, Ronglih Chen, Zhih-Cherng Huang, Po-Sen Wu, Nan-Chun
貢獻者:	Natl Sun Yat Sen Univ, Sch Med Natl Sun Yat Sen Univ, Coll Med, Doctoral Program Clin & Expt Med Natl Sun Yat Sen Univ, Ctr Excellence Metab Associated Fatty Liver Dis Chi Mei Med Ctr, Dept Internal Med, Div Cardiol Natl Sun Yat Sen Univ, Coll Med, Sch Med Chi Mei Med Ctr, Dept Internal Med, Div Nephrol Chung Hwa Univ Med Technol, Dept Med Lab Sci & Biotechnol Chi Mei Med Ctr, Dept Surg, Div Plast Surg Johns Hopkins Univ Hosp Cedars Sinai Med Ctr, Smidt Heart Inst, Dept Cardiol Stanford Univ, Sch Med, Stanford Cardiovasc Inst Harvard Med Sch, Brigham & Womens Hosp, Dept Med Chi Mei Med Ctr, Dept Surg, Div Cardiovasc Surg Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
關鍵字:	Signal intensity coefficient Aortic stenosis Cardiovascular death Myocardial fibrosis
日期:	2024
上傳時間:	2024-12-25 11:04:46 (UTC+8)
出版者:	ELSEVIER IRELAND LTD
摘要:	Objective: Despite advanced aortic valve replacement techniques, aortic stenosis (AS)-induced irreversible myocardial fibrosis contributes to poorer outcomes. Therefore, in addition to early diagnosis of AS, detecting myocardial fibrosis is crucial for physicians to determine the timing of surgery. The Signal Intensity Coefficient (SIC) was used to detect subtle myocardial deformation. Hence, we aimed to investigate whether SIC correlated with myocardial dysfunction and fibrosis from both clinical and preclinical perspectives.Methods: We collected medical records and echocardiography images, including the SIC of patients who underwent surgical aortic valve replacement (AVR) for AS from 2010 to 2015. The endpoint of the study was mortality. Median follow-up period was 80 months. Results: Among 109 patients, 15 died due to cardiovascular causes. Although SIC decreased in all patients postAVR, patients with an SIC >= 0.34 before surgeries presented with a higher probability of cardiovascular death. In contrast, changes in the left ventricular (LV) ejection fraction, LV mass index, and LV volume failed to predict outcomes. Similarly, SIC was obtained in mice undergoing aortic banding and debanding surgery for comparison with the degree of myocardial fibrosis. SIC was continuously elevated after aortic banding and declined gradually after debanding surgery in mice. Debanding surgery indicated the regression of aortic banding-induced myocardial fibrosis.Conclusion: Pre-AVR SIC was associated with the risk of cardiovascular death and reflected the degree of myocardial fibrosis. Further investigations are required to study the clinical application of SIC in patients with AS.
關聯:	International Journal of Cardiology, v.394, Article 131367
显示于类别:	[行政單位] 456

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	7	检视/开启

在CNU IR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....