Signal intensity coefficient as a detector of aortic stenosis-induced myocardial fibrosis and its correlation to the long term outcome

doi:10.1016/j.ijcard.2023.131367

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Title:	Signal intensity coefficient as a detector of aortic stenosis-induced myocardial fibrosis and its correlation to the long term outcome
Authors:	Chang, Wei-Ting Lin, Chih-Hsien Lee, Wei-Chieh Kan, Wei-Chih Lin, You-Cheng Hiremath, Pranoti Cheng, Susan Liao, Ronglih Chen, Zhih-Cherng Huang, Po-Sen Wu, Nan-Chun
Contributors:	Natl Sun Yat Sen Univ, Sch Med Natl Sun Yat Sen Univ, Coll Med, Doctoral Program Clin & Expt Med Natl Sun Yat Sen Univ, Ctr Excellence Metab Associated Fatty Liver Dis Chi Mei Med Ctr, Dept Internal Med, Div Cardiol Natl Sun Yat Sen Univ, Coll Med, Sch Med Chi Mei Med Ctr, Dept Internal Med, Div Nephrol Chung Hwa Univ Med Technol, Dept Med Lab Sci & Biotechnol Chi Mei Med Ctr, Dept Surg, Div Plast Surg Johns Hopkins Univ Hosp Cedars Sinai Med Ctr, Smidt Heart Inst, Dept Cardiol Stanford Univ, Sch Med, Stanford Cardiovasc Inst Harvard Med Sch, Brigham & Womens Hosp, Dept Med Chi Mei Med Ctr, Dept Surg, Div Cardiovasc Surg Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
Keywords:	Signal intensity coefficient Aortic stenosis Cardiovascular death Myocardial fibrosis
Date:	2024
Issue Date:	2024-12-25 11:04:46 (UTC+8)
Publisher:	ELSEVIER IRELAND LTD
Abstract:	Objective: Despite advanced aortic valve replacement techniques, aortic stenosis (AS)-induced irreversible myocardial fibrosis contributes to poorer outcomes. Therefore, in addition to early diagnosis of AS, detecting myocardial fibrosis is crucial for physicians to determine the timing of surgery. The Signal Intensity Coefficient (SIC) was used to detect subtle myocardial deformation. Hence, we aimed to investigate whether SIC correlated with myocardial dysfunction and fibrosis from both clinical and preclinical perspectives.Methods: We collected medical records and echocardiography images, including the SIC of patients who underwent surgical aortic valve replacement (AVR) for AS from 2010 to 2015. The endpoint of the study was mortality. Median follow-up period was 80 months. Results: Among 109 patients, 15 died due to cardiovascular causes. Although SIC decreased in all patients postAVR, patients with an SIC >= 0.34 before surgeries presented with a higher probability of cardiovascular death. In contrast, changes in the left ventricular (LV) ejection fraction, LV mass index, and LV volume failed to predict outcomes. Similarly, SIC was obtained in mice undergoing aortic banding and debanding surgery for comparison with the degree of myocardial fibrosis. SIC was continuously elevated after aortic banding and declined gradually after debanding surgery in mice. Debanding surgery indicated the regression of aortic banding-induced myocardial fibrosis.Conclusion: Pre-AVR SIC was associated with the risk of cardiovascular death and reflected the degree of myocardial fibrosis. Further investigations are required to study the clinical application of SIC in patients with AS.
Relation:	International Journal of Cardiology, v.394, Article 131367
Appears in Collections:	[Dept. of Hospital and Health (including master's program)] Periodical Articles

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