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| 標題: | Attenuation of blue light-induced photo-oxidative stress through inhibition of NF-κB and MAPK signaling pathways, and activation of Nrf2 signaling pathway by djulis and its bioactive compounds |
| 作者: | Liu, Ching-Chih
Chu, Chin -Chen
Chen, Shih-Ying
Lin, Ying-Chun
Duh, Pin -Der |
| 貢獻者: | Chi Mei Med Ctr, Dept Ophthalmol
Chi Mei Med Ctr, Dept Anesthesiol
Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol |
| 關鍵字: | Djulis ( Chenopodium formosanum )
Bioactive compounds
Blue light irradiation
Retinal pigment epithelium (RPE) cells
MAPK
Nrf2 |
| 日期: | 2023 |
| 上傳時間: | 2024-12-25 11:04:17 (UTC+8) |
| 出版者: | ELSEVIER |
| 摘要: | The aim of this study is to investigate the djulis and its bioactive compounds to prevent blue light (BL)-induced photo-oxidative stress in ARPE-19 cells. After 6 h of BL exposure (peak at 452 nm), ARPE-19 cell viability significantly decreased, but treatment with water extract of djulis (WECF) at 0.1-25 mu g/mL protected the cells from BL-induced phototoxicity. The cytoprotective effect of WECF were associated with a decrease in BL-induced oxidative stress and caspase-3 activity, and an increase in GSH levels and SOD activity. WECF also inhibited the expression of NF-kappa B protein and the MAPK signaling pathway, while upregulated heme oxygenase-1 (HO-1) via the Nrf2-mediated pathway. Moreover, betanin, kaempferol, quercetin and rutin, present in WECF, showed a protective effect against BL-induced photo-oxidative stress at 1-10 mu M. Overall, WECF and its bioactive com-pounds have the potential to protect ARPE-19 cells from BL-induced retina damage, which could have thera-peutic implications for retinal disease. |
| 關聯: | Journal of Functional Foods, v.109, Article 105797 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
[ 食品科技系 ] 期刊論文
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