Attenuation of blue light-induced photo-oxidative stress through inhibition of NF-κB and MAPK signaling pathways, and activation of Nrf2 signaling pathway by djulis and its bioactive compounds

doi:10.1016/j.jff.2023.105797

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 保健營養系(所) > 期刊論文 > Item 310902800/34836

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/34836

標題:	Attenuation of blue light-induced photo-oxidative stress through inhibition of NF-κB and MAPK signaling pathways, and activation of Nrf2 signaling pathway by djulis and its bioactive compounds
作者:	Liu, Ching-Chih Chu, Chin -Chen Chen, Shih-Ying Lin, Ying-Chun Duh, Pin -Der
貢獻者:	Chi Mei Med Ctr, Dept Ophthalmol Chi Mei Med Ctr, Dept Anesthesiol Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol
關鍵字:	Djulis ( Chenopodium formosanum ) Bioactive compounds Blue light irradiation Retinal pigment epithelium (RPE) cells MAPK Nrf2
日期:	2023
上傳時間:	2024-12-25 11:04:17 (UTC+8)
出版者:	ELSEVIER
摘要:	The aim of this study is to investigate the djulis and its bioactive compounds to prevent blue light (BL)-induced photo-oxidative stress in ARPE-19 cells. After 6 h of BL exposure (peak at 452 nm), ARPE-19 cell viability significantly decreased, but treatment with water extract of djulis (WECF) at 0.1-25 mu g/mL protected the cells from BL-induced phototoxicity. The cytoprotective effect of WECF were associated with a decrease in BL-induced oxidative stress and caspase-3 activity, and an increase in GSH levels and SOD activity. WECF also inhibited the expression of NF-kappa B protein and the MAPK signaling pathway, while upregulated heme oxygenase-1 (HO-1) via the Nrf2-mediated pathway. Moreover, betanin, kaempferol, quercetin and rutin, present in WECF, showed a protective effect against BL-induced photo-oxidative stress at 1-10 mu M. Overall, WECF and its bioactive com-pounds have the potential to protect ARPE-19 cells from BL-induced retina damage, which could have thera-peutic implications for retinal disease.
關聯:	Journal of Functional Foods, v.109, Article 105797
显示于类别:	[保健營養系(所) ] 期刊論文 [ 食品科技系 ] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	5	检视/开启
j.jff.2023.105797.pdf		2703Kb	Adobe PDF	4	检视/开启

在CNU IR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....