Attenuation of blue light-induced photo-oxidative stress through inhibition of NF-κB and MAPK signaling pathways, and activation of Nrf2 signaling pathway by djulis and its bioactive compounds

doi:10.1016/j.jff.2023.105797

CNU IR > Pharmacy and Science > Dept. of Health and Nutrition (including master's program) > Periodical Articles > Item 310902800/34836

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34836

Title:	Attenuation of blue light-induced photo-oxidative stress through inhibition of NF-κB and MAPK signaling pathways, and activation of Nrf2 signaling pathway by djulis and its bioactive compounds
Authors:	Liu, Ching-Chih Chu, Chin -Chen Chen, Shih-Ying Lin, Ying-Chun Duh, Pin -Der
Contributors:	Chi Mei Med Ctr, Dept Ophthalmol Chi Mei Med Ctr, Dept Anesthesiol Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol
Keywords:	Djulis ( Chenopodium formosanum ) Bioactive compounds Blue light irradiation Retinal pigment epithelium (RPE) cells MAPK Nrf2
Date:	2023
Issue Date:	2024-12-25 11:04:17 (UTC+8)
Publisher:	ELSEVIER
Abstract:	The aim of this study is to investigate the djulis and its bioactive compounds to prevent blue light (BL)-induced photo-oxidative stress in ARPE-19 cells. After 6 h of BL exposure (peak at 452 nm), ARPE-19 cell viability significantly decreased, but treatment with water extract of djulis (WECF) at 0.1-25 mu g/mL protected the cells from BL-induced phototoxicity. The cytoprotective effect of WECF were associated with a decrease in BL-induced oxidative stress and caspase-3 activity, and an increase in GSH levels and SOD activity. WECF also inhibited the expression of NF-kappa B protein and the MAPK signaling pathway, while upregulated heme oxygenase-1 (HO-1) via the Nrf2-mediated pathway. Moreover, betanin, kaempferol, quercetin and rutin, present in WECF, showed a protective effect against BL-induced photo-oxidative stress at 1-10 mu M. Overall, WECF and its bioactive com-pounds have the potential to protect ARPE-19 cells from BL-induced retina damage, which could have thera-peutic implications for retinal disease.
Relation:	Journal of Functional Foods, v.109, Article 105797
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles [Dept. of Food Science & Technology] Periodical Articles

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