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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34670


    標題: Formin-Like 2 Is a Potential Biomarker of Poor Prognosis in Nasopharyngeal Carcinoma
    作者: Lee, Sung-Wei
    Yang, Ching-Chieh
    Lai, Hong-Yue
    Tsai, Hsin-Hwa
    Yeh, Cheng-Fa
    Kuo, Yu-Hsuan
    Kang, Nai-Wen
    Chen, Tzu-Ju
    Chang, Shih-Lun
    貢獻者: Chi Mei Hospital
    Chi Mei Hospital
    Department of Pharmacy, Chia Nan University of Pharmacy & Science
    Chi Mei Hospital
    Chi Mei Hospital
    Chi Mei Hospital
    Chi Mei Hospital
    Chia Nan University of Pharmacy & Science
    Chung Hua University
    Chi Mei Hospital
    National Sun Yat Sen University
    Chi Mei Hospital
    關鍵字: cancer
    invasion
    fmnl2
    cytoskeleton
    pathway
    日期: 2022
    上傳時間: 2023-12-11 14:04:09 (UTC+8)
    出版者: KARGER
    摘要: Introduction: Nasopharyngeal carcinoma (NPC) is the most common malignant tumor in southern China and Southeast Asia. Although substantial research on NPC has been conducted, the resulting improvement in clinical outcomes remains very disappointing. NPC treatment typically involves radiation therapy and chemotherapy, but the high incidence of metastasis and recurrence in NPC patients result in poor survival. Therefore, identifying potential biomarkers and discovering therapeutic targets are necessary to design tailored treatments based on the genetic profiles of NPC patients. Methods: Correlations of protein immunostaining with clinicopathological features were analyzed by Pearson's chi(2) test. The Kaplan-Meier method with a log-rank test was used to generate survival curves. Multivariate analysis was performed using the Cox proportional hazards model. Results: In this study, we comparatively analyzed cytoskeletal organization and biogenesis (GO:0007010) and tumorigenesis in the NPC transcriptome (GSE12452) and found that formin-like 2 (FMNL2) expression was significantly upregulated in NPC tumor tissues. Moreover, high FMNL2 expression was significantly correlated with primary tumor stage (p = 0.001), lymph node status (p = 0.004), cancer stage (p = 0.006), and histological grade (p = 0.040). More importantly, high FMNL2 expression was significantly correlated with poor survival in NPC patients according to univariate analysis and multivariate analysis. Conclusion: This study reveals that FMNL2 may be an important potential biomarker for evaluating the prognosis of NPC patients.
    關聯: Oncology, v.100, n.9, pp.475-484
    Appears in Collections:[藥學系(所)] 期刊論文
    [化妝品應用與管理系(所)] 期刊論文

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