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https://ir.cnu.edu.tw/handle/310902800/34670
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| 標題: | Formin-Like 2 Is a Potential Biomarker of Poor Prognosis in Nasopharyngeal Carcinoma |
| 作者: | Lee, Sung-Wei
Yang, Ching-Chieh
Lai, Hong-Yue
Tsai, Hsin-Hwa
Yeh, Cheng-Fa
Kuo, Yu-Hsuan
Kang, Nai-Wen
Chen, Tzu-Ju
Chang, Shih-Lun |
| 貢獻者: | Chi Mei Hospital
Chi Mei Hospital
Department of Pharmacy, Chia Nan University of Pharmacy & Science
Chi Mei Hospital
Chi Mei Hospital
Chi Mei Hospital
Chi Mei Hospital
Chia Nan University of Pharmacy & Science
Chung Hua University
Chi Mei Hospital
National Sun Yat Sen University
Chi Mei Hospital |
| 關鍵字: | cancer
invasion
fmnl2
cytoskeleton
pathway |
| 日期: | 2022 |
| 上傳時間: | 2023-12-11 14:04:09 (UTC+8) |
| 出版者: | KARGER |
| 摘要: | Introduction: Nasopharyngeal carcinoma (NPC) is the most common malignant tumor in southern China and Southeast Asia. Although substantial research on NPC has been conducted, the resulting improvement in clinical outcomes remains very disappointing. NPC treatment typically involves radiation therapy and chemotherapy, but the high incidence of metastasis and recurrence in NPC patients result in poor survival. Therefore, identifying potential biomarkers and discovering therapeutic targets are necessary to design tailored treatments based on the genetic profiles of NPC patients. Methods: Correlations of protein immunostaining with clinicopathological features were analyzed by Pearson's chi(2) test. The Kaplan-Meier method with a log-rank test was used to generate survival curves. Multivariate analysis was performed using the Cox proportional hazards model. Results: In this study, we comparatively analyzed cytoskeletal organization and biogenesis (GO:0007010) and tumorigenesis in the NPC transcriptome (GSE12452) and found that formin-like 2 (FMNL2) expression was significantly upregulated in NPC tumor tissues. Moreover, high FMNL2 expression was significantly correlated with primary tumor stage (p = 0.001), lymph node status (p = 0.004), cancer stage (p = 0.006), and histological grade (p = 0.040). More importantly, high FMNL2 expression was significantly correlated with poor survival in NPC patients according to univariate analysis and multivariate analysis. Conclusion: This study reveals that FMNL2 may be an important potential biomarker for evaluating the prognosis of NPC patients. |
| 關聯: | Oncology, v.100, n.9, pp.475-484 |
| 显示于类别: | [Dept. of Pharmacy] Periodical Articles
[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles
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