Formin-Like 2 Is a Potential Biomarker of Poor Prognosis in Nasopharyngeal Carcinoma

doi:10.1159/000525682

CNU IR > Pharmacy and Science > Dept. of Pharmacy > Periodical Articles > Item 310902800/34670

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34670

Title:	Formin-Like 2 Is a Potential Biomarker of Poor Prognosis in Nasopharyngeal Carcinoma
Authors:	Lee, Sung-Wei Yang, Ching-Chieh Lai, Hong-Yue Tsai, Hsin-Hwa Yeh, Cheng-Fa Kuo, Yu-Hsuan Kang, Nai-Wen Chen, Tzu-Ju Chang, Shih-Lun
Contributors:	Chi Mei Hospital Chi Mei Hospital Department of Pharmacy, Chia Nan University of Pharmacy & Science Chi Mei Hospital Chi Mei Hospital Chi Mei Hospital Chi Mei Hospital Chia Nan University of Pharmacy & Science Chung Hua University Chi Mei Hospital National Sun Yat Sen University Chi Mei Hospital
Keywords:	cancer invasion fmnl2 cytoskeleton pathway
Date:	2022
Issue Date:	2023-12-11 14:04:09 (UTC+8)
Publisher:	KARGER
Abstract:	Introduction: Nasopharyngeal carcinoma (NPC) is the most common malignant tumor in southern China and Southeast Asia. Although substantial research on NPC has been conducted, the resulting improvement in clinical outcomes remains very disappointing. NPC treatment typically involves radiation therapy and chemotherapy, but the high incidence of metastasis and recurrence in NPC patients result in poor survival. Therefore, identifying potential biomarkers and discovering therapeutic targets are necessary to design tailored treatments based on the genetic profiles of NPC patients. Methods: Correlations of protein immunostaining with clinicopathological features were analyzed by Pearson's chi(2) test. The Kaplan-Meier method with a log-rank test was used to generate survival curves. Multivariate analysis was performed using the Cox proportional hazards model. Results: In this study, we comparatively analyzed cytoskeletal organization and biogenesis (GO:0007010) and tumorigenesis in the NPC transcriptome (GSE12452) and found that formin-like 2 (FMNL2) expression was significantly upregulated in NPC tumor tissues. Moreover, high FMNL2 expression was significantly correlated with primary tumor stage (p = 0.001), lymph node status (p = 0.004), cancer stage (p = 0.006), and histological grade (p = 0.040). More importantly, high FMNL2 expression was significantly correlated with poor survival in NPC patients according to univariate analysis and multivariate analysis. Conclusion: This study reveals that FMNL2 may be an important potential biomarker for evaluating the prognosis of NPC patients.
Relation:	Oncology, v.100, n.9, pp.475-484
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles [Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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