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| 標題: | Antimicrobial ability and mechanism analysis of Lactobacillus species against carbapenemase-producing Enterobacteriaceae |
| 作者: | Chen, Chi-Chung
Lai, Chih-Cheng
Huang, Hui-Ling
Su, Yu-Ting
Chiu, Yu-Hsin
Toh, Han-Siong
Chiang, Shyh-Ren
Chuang, Yin-Ching
Lu, Ying-Chen
Tang, Hung-Jen |
| 貢獻者: | Chi Mei Med Ctr, Dept Med Res
Natl Chiayi Univ, Dept Food Sci
Kaohsiung Vet Gen Hosp, Dept Internal Med, Tainan Branch
Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
Chi Mei Med Ctr, Dept Internal Med
Chi Mei Med Ctr, Dept Internal Med |
| 關鍵字: | Lactobacillus
Carbapenemase-producing Enterobacte-riaceae
Organic acid
Lactic acid
In vitro activity |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:50:08 (UTC+8) |
| 出版者: | ELSEVIER TAIWAN |
| 摘要: | Background: This study aims to investigate the antimicrobial ability and mechanism analysis of Lactobacillus species against carbapenemase-producing Enterobacteriaceae (CPE). Methods: Five Lactobacillus spp. strains and 18 CPE clinical isolates were collected. Their antiCPE effects were assessed by agar well diffusion and broth microdilution assay, as well as time kill test. Finally, the specific anti-CPE mechanism, especially for the effect of organic acids was determined using broth microdilution method. Results: All of five Lactobacilli isolates displayed the potent activity against most CPE isolates with mean zones of inhibition ranging 10.2-21.1 mm. The anti-CPE activity was not affected by heating, catalase, and proteinase treatment. Under the concentration of 50% LUC0180 cell free supernatant (CFS), lactic acid, and mix acid could totally inhibit the growth of carbapenem-resistant Klebsiella pneumoniae (CPE0011), and acetic acid could inhibit 67.8%. In contrast, succinic acid and citric acid could not inhibit the growth of CPE0011. While we decreased the concentration to 25%, only lactic acid and mix acid displayed 100% inhibition. In contrast, succinic acid, citric acid and acetic acid did not show any inhibitory effect. Conclusions: Lactobacillus strains exhibit potent anti-CPE activity, and lactic acid produced by Lactobacillus strains is the major antimicrobial mechanism. Copyright & ordf; 2020, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/). |
| 關聯: | J MICROBIOL IMMUNOL, v.54, n.3, pp.447-456 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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