Antimicrobial ability and mechanism analysis of Lactobacillus species against carbapenemase-producing Enterobacteriaceae

doi:10.1016/j.jmii.2020.01.005

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 保健營養系(所) > 期刊論文 > Item 310902800/34406

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/34406

標題:	Antimicrobial ability and mechanism analysis of Lactobacillus species against carbapenemase-producing Enterobacteriaceae
作者:	Chen, Chi-Chung Lai, Chih-Cheng Huang, Hui-Ling Su, Yu-Ting Chiu, Yu-Hsin Toh, Han-Siong Chiang, Shyh-Ren Chuang, Yin-Ching Lu, Ying-Chen Tang, Hung-Jen
貢獻者:	Chi Mei Med Ctr, Dept Med Res Natl Chiayi Univ, Dept Food Sci Kaohsiung Vet Gen Hosp, Dept Internal Med, Tainan Branch Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Chi Mei Med Ctr, Dept Internal Med Chi Mei Med Ctr, Dept Internal Med
關鍵字:	Lactobacillus Carbapenemase-producing Enterobacte-riaceae Organic acid Lactic acid In vitro activity
日期:	2021
上傳時間:	2023-11-11 11:50:08 (UTC+8)
出版者:	ELSEVIER TAIWAN
摘要:	Background: This study aims to investigate the antimicrobial ability and mechanism analysis of Lactobacillus species against carbapenemase-producing Enterobacteriaceae (CPE). Methods: Five Lactobacillus spp. strains and 18 CPE clinical isolates were collected. Their antiCPE effects were assessed by agar well diffusion and broth microdilution assay, as well as time kill test. Finally, the specific anti-CPE mechanism, especially for the effect of organic acids was determined using broth microdilution method. Results: All of five Lactobacilli isolates displayed the potent activity against most CPE isolates with mean zones of inhibition ranging 10.2-21.1 mm. The anti-CPE activity was not affected by heating, catalase, and proteinase treatment. Under the concentration of 50% LUC0180 cell free supernatant (CFS), lactic acid, and mix acid could totally inhibit the growth of carbapenem-resistant Klebsiella pneumoniae (CPE0011), and acetic acid could inhibit 67.8%. In contrast, succinic acid and citric acid could not inhibit the growth of CPE0011. While we decreased the concentration to 25%, only lactic acid and mix acid displayed 100% inhibition. In contrast, succinic acid, citric acid and acetic acid did not show any inhibitory effect. Conclusions: Lactobacillus strains exhibit potent anti-CPE activity, and lactic acid produced by Lactobacillus strains is the major antimicrobial mechanism. Copyright & ordf; 2020, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
關聯:	J MICROBIOL IMMUNOL, v.54, n.3, pp.447-456
显示于类别:	[保健營養系(所) ] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	225	检视/开启
j.jmii.2020.01.005.pdf		1888Kb	Adobe PDF	98	检视/开启

在CNU IR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....