資料載入中.....
|
請使用永久網址來引用或連結此文件:
https://ir.cnu.edu.tw/handle/310902800/34115
|
| 標題: | Comparison of antiplatelet antibody profiles between hepatitis C virus-associated immune thrombocytopenia and primary immune thrombocytopenia |
| 作者: | Huang, Cih-En
Chen, Wei-Ming
Wu, Yu-Ying
Shen, Chien-Heng
Hsu, Chia-Chen
Li, Chian-Pei
Chen, Min-Chi
Chang, Jung-Jung
Chen, Yi-Yang
Lu, Chang-Hsien
Shi, Chung-Sheng
Chen, Chih-Cheng |
| 貢獻者: | Chang Gung Mem Hosp, Dept Med, Div Hematol & Oncol
Chang Gung Univ, Grad Inst Clin Med Sci
Chang Gung Mem Hosp, Dept Med, Div Gastroenterol & Hepatol
Chang Gung Univ, Coll Med
Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
Chang Gung Univ, Dept Publ Hlth
Chang Gung Univ, Biostat Consulting Ctr
Chang Gung Mem Hosp, Dept Med, Div Cardiol
Chang Gung Mem Hosp, Dept Surg, Div Urol |
| 關鍵字: | Antiplatelet antibody
glycoprotein
hepatitis C virus
human leukocyte antigen
immune thrombocytopenia |
| 日期: | 2021 |
| 上傳時間: | 2022-11-18 11:24:30 (UTC+8) |
| 出版者: | Taylor & Francis Inc |
| 摘要: | Hepatitis C virus-associated immune thrombocytopenia (HCV-ITP) has been assumed to be one of secondary ITP and associated with antiplatelet antibodies. This study was to clarify the antibody profile in HCV-ITP compared with primary ITP. We enrolled 55 HCV-ITP, 30 primary ITP, 11Helicobacter pylori-ITP, 21 HCV control, and 16 healthy volunteers. We reviewed their blood cell counts, autoimmune markers, and spleen size. We used enzyme-linked immunosorbent assay kit to detect the specific antibody to glycoproteins IIb/IIIa, Ia/IIa, Ib/IX, IV, and human leukocyte antigen (HLA) class I. Compared with primary ITP patients, HCV-ITP patients had an older age, lower white blood cell (WBC) count and fewer presented with severe thrombocytopenia. The rate of positive antibody detection was 63.6% for the HCV-ITP group higher than the rate of 40% for the primary ITP. In the HCV control, antiplatelet antibodies were detected in 38.1% patients and no one had more than two types of antibodies. The antiplatelet antibodies correlated to severer thrombocytopenia. An HLA class I antibody was associated with lower WBCs and larger spleen. In conclusion, HCV-ITP patients had a high rate of positive antiplatelet antibody. The antibodies were associated with not only lower platelets but also leukopenia and splenomegaly. |
| 關聯: | Platelets, v.32, n.8, pp.8 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
|
文件中的檔案:
| 檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
|---|
| index.html | | 0Kb | HTML | 545 | 檢視/開啟 |
|
在CNU IR中所有的資料項目都受到原著作權保護.
|
