Comparison of antiplatelet antibody profiles between hepatitis C virus-associated immune thrombocytopenia and primary immune thrombocytopenia

doi:10.1080/09537104.2020.1820975

CNU IR > Pharmacy and Science > Dept. of Health and Nutrition (including master's program) > Periodical Articles > Item 310902800/34115

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34115

Title:	Comparison of antiplatelet antibody profiles between hepatitis C virus-associated immune thrombocytopenia and primary immune thrombocytopenia
Authors:	Huang, Cih-En Chen, Wei-Ming Wu, Yu-Ying Shen, Chien-Heng Hsu, Chia-Chen Li, Chian-Pei Chen, Min-Chi Chang, Jung-Jung Chen, Yi-Yang Lu, Chang-Hsien Shi, Chung-Sheng Chen, Chih-Cheng
Contributors:	Chang Gung Mem Hosp, Dept Med, Div Hematol & Oncol Chang Gung Univ, Grad Inst Clin Med Sci Chang Gung Mem Hosp, Dept Med, Div Gastroenterol & Hepatol Chang Gung Univ, Coll Med Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Chang Gung Univ, Dept Publ Hlth Chang Gung Univ, Biostat Consulting Ctr Chang Gung Mem Hosp, Dept Med, Div Cardiol Chang Gung Mem Hosp, Dept Surg, Div Urol
Keywords:	Antiplatelet antibody glycoprotein hepatitis C virus human leukocyte antigen immune thrombocytopenia
Date:	2021
Issue Date:	2022-11-18 11:24:30 (UTC+8)
Publisher:	Taylor & Francis Inc
Abstract:	Hepatitis C virus-associated immune thrombocytopenia (HCV-ITP) has been assumed to be one of secondary ITP and associated with antiplatelet antibodies. This study was to clarify the antibody profile in HCV-ITP compared with primary ITP. We enrolled 55 HCV-ITP, 30 primary ITP, 11Helicobacter pylori-ITP, 21 HCV control, and 16 healthy volunteers. We reviewed their blood cell counts, autoimmune markers, and spleen size. We used enzyme-linked immunosorbent assay kit to detect the specific antibody to glycoproteins IIb/IIIa, Ia/IIa, Ib/IX, IV, and human leukocyte antigen (HLA) class I. Compared with primary ITP patients, HCV-ITP patients had an older age, lower white blood cell (WBC) count and fewer presented with severe thrombocytopenia. The rate of positive antibody detection was 63.6% for the HCV-ITP group higher than the rate of 40% for the primary ITP. In the HCV control, antiplatelet antibodies were detected in 38.1% patients and no one had more than two types of antibodies. The antiplatelet antibodies correlated to severer thrombocytopenia. An HLA class I antibody was associated with lower WBCs and larger spleen. In conclusion, HCV-ITP patients had a high rate of positive antiplatelet antibody. The antibodies were associated with not only lower platelets but also leukopenia and splenomegaly.
Relation:	Platelets, v.32, n.8, pp.8
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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