Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/34115
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    標題: Comparison of antiplatelet antibody profiles between hepatitis C virus-associated immune thrombocytopenia and primary immune thrombocytopenia
    作者: Huang, Cih-En
    Chen, Wei-Ming
    Wu, Yu-Ying
    Shen, Chien-Heng
    Hsu, Chia-Chen
    Li, Chian-Pei
    Chen, Min-Chi
    Chang, Jung-Jung
    Chen, Yi-Yang
    Lu, Chang-Hsien
    Shi, Chung-Sheng
    Chen, Chih-Cheng
    貢獻者: Chang Gung Mem Hosp, Dept Med, Div Hematol & Oncol
    Chang Gung Univ, Grad Inst Clin Med Sci
    Chang Gung Mem Hosp, Dept Med, Div Gastroenterol & Hepatol
    Chang Gung Univ, Coll Med
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Chang Gung Univ, Dept Publ Hlth
    Chang Gung Univ, Biostat Consulting Ctr
    Chang Gung Mem Hosp, Dept Med, Div Cardiol
    Chang Gung Mem Hosp, Dept Surg, Div Urol
    關鍵字: Antiplatelet antibody
    glycoprotein
    hepatitis C virus
    human leukocyte antigen
    immune thrombocytopenia
    日期: 2021
    上傳時間: 2022-11-18 11:24:30 (UTC+8)
    出版者: Taylor & Francis Inc
    摘要: Hepatitis C virus-associated immune thrombocytopenia (HCV-ITP) has been assumed to be one of secondary ITP and associated with antiplatelet antibodies. This study was to clarify the antibody profile in HCV-ITP compared with primary ITP. We enrolled 55 HCV-ITP, 30 primary ITP, 11Helicobacter pylori-ITP, 21 HCV control, and 16 healthy volunteers. We reviewed their blood cell counts, autoimmune markers, and spleen size. We used enzyme-linked immunosorbent assay kit to detect the specific antibody to glycoproteins IIb/IIIa, Ia/IIa, Ib/IX, IV, and human leukocyte antigen (HLA) class I. Compared with primary ITP patients, HCV-ITP patients had an older age, lower white blood cell (WBC) count and fewer presented with severe thrombocytopenia. The rate of positive antibody detection was 63.6% for the HCV-ITP group higher than the rate of 40% for the primary ITP. In the HCV control, antiplatelet antibodies were detected in 38.1% patients and no one had more than two types of antibodies. The antiplatelet antibodies correlated to severer thrombocytopenia. An HLA class I antibody was associated with lower WBCs and larger spleen. In conclusion, HCV-ITP patients had a high rate of positive antiplatelet antibody. The antibodies were associated with not only lower platelets but also leukopenia and splenomegaly.
    關聯: Platelets, v.32, n.8, pp.8
    显示于类别:[保健營養系(所) ] 期刊論文

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