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https://ir.cnu.edu.tw/handle/310902800/32631
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| 標題: | Association between neurodegenerative diseases and pneumonia: a retrospective population-based study |
| 作者: | Yeh, Jun-Jun(葉俊濬)
Lin, Cheng-Li
Hsu, Chung Y.
Shae, Zon-Yin
Kao, Chia-Hung |
| 貢獻者: | Chia Yi Christian Hosp, Ditmanson Med Fdn
Chia Nan Univ Pharm & Sci
Meiho Univ
China Med Univ
China Med Univ Hosp, Management Off Hlth Data
China Med Univ, Coll Med
China Med Univ, Coll Med, Grad Inst Biomed Sci
Asia Univ, Dept Comp Sci & Informat Engn
China Med Univ Hosp, Dept Nucl Med
China Med Univ Hosp, PET Ctr
Asia Univ, Dept Bioinformat & Med Engn |
| 關鍵字: | Pneumonia
neurodegenerative diseases
statin
population-based study |
| 日期: | 2019-06 |
| 上傳時間: | 2020-07-29 13:52:56 (UTC+8) |
| 出版者: | TAYLOR & FRANCIS LTD |
| 摘要: | Purpose: The association between pneumonia and neurodegenerative diseases (NDs) has never been reported in detail. We address this relationship with reference to the general population. Methods: Using Taiwan's National Health Insurance Research Database to identify a pneumonia cohort (including the typical and atypical), we established an ND cohort of 19,062 patients and a non-ND cohort of 76,227 people. In both cohorts, the risk of pneumonia was measured using multivariable Cox proportional hazards models. Results: The adjusted hazard ratio (aHR) (95% confidence interval [CI]) for the pneumonia cohort was 2.10 (1.96-2.24), regardless of age, sex, comorbidities or drug use in the ND cohort. The aHR (95% CI) for adults aged 20-49 years was 2.08 (1.58-2.75), men 2.20 (2.01-2.40). However, older subjects were at greatest risk of pneumonia, (3.41 [2.99-3.88]) if the 20-49 years age group is used as the reference. For the ND and non-ND cohorts, those with comorbidities (with the exception of hyperlipidemia) had higher risk; aHR (95% CI) 2.35 (2.30-2.52). The aHR (95% CI) for those without comorbidities is 3.28 (2.52-4.26). No significant difference was observed in incidence of pneumonia between those who were and were not using statin medications; the aHR (95% CI) was 1.03 (0.93-1.14). Conclusion: The ND cohort had a higher risk of pneumonia, regardless of age, sex, comorbidities or statin use. The risk of pneumonia was higher in elderly and male patients in the ND cohort. |
| 關聯: | Current Medical Research and Opinion, v.35, n.6, pp.1033-1039 |
| 顯示於類別: | [嬰幼兒保育系] 期刊論文
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