Association between neurodegenerative diseases and pneumonia: a retrospective population-based study

doi:10.1080/03007995.2018.1552408

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Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/32631

Title:	Association between neurodegenerative diseases and pneumonia: a retrospective population-based study
Authors:	Yeh, Jun-Jun(葉俊濬) Lin, Cheng-Li Hsu, Chung Y. Shae, Zon-Yin Kao, Chia-Hung
Contributors:	Chia Yi Christian Hosp, Ditmanson Med Fdn Chia Nan Univ Pharm & Sci Meiho Univ China Med Univ China Med Univ Hosp, Management Off Hlth Data China Med Univ, Coll Med China Med Univ, Coll Med, Grad Inst Biomed Sci Asia Univ, Dept Comp Sci & Informat Engn China Med Univ Hosp, Dept Nucl Med China Med Univ Hosp, PET Ctr Asia Univ, Dept Bioinformat & Med Engn
Keywords:	Pneumonia neurodegenerative diseases statin population-based study
Date:	2019-06
Issue Date:	2020-07-29 13:52:56 (UTC+8)
Publisher:	TAYLOR & FRANCIS LTD
Abstract:	Purpose: The association between pneumonia and neurodegenerative diseases (NDs) has never been reported in detail. We address this relationship with reference to the general population. Methods: Using Taiwan's National Health Insurance Research Database to identify a pneumonia cohort (including the typical and atypical), we established an ND cohort of 19,062 patients and a non-ND cohort of 76,227 people. In both cohorts, the risk of pneumonia was measured using multivariable Cox proportional hazards models. Results: The adjusted hazard ratio (aHR) (95% confidence interval [CI]) for the pneumonia cohort was 2.10 (1.96-2.24), regardless of age, sex, comorbidities or drug use in the ND cohort. The aHR (95% CI) for adults aged 20-49 years was 2.08 (1.58-2.75), men 2.20 (2.01-2.40). However, older subjects were at greatest risk of pneumonia, (3.41 [2.99-3.88]) if the 20-49 years age group is used as the reference. For the ND and non-ND cohorts, those with comorbidities (with the exception of hyperlipidemia) had higher risk; aHR (95% CI) 2.35 (2.30-2.52). The aHR (95% CI) for those without comorbidities is 3.28 (2.52-4.26). No significant difference was observed in incidence of pneumonia between those who were and were not using statin medications; the aHR (95% CI) was 1.03 (0.93-1.14). Conclusion: The ND cohort had a higher risk of pneumonia, regardless of age, sex, comorbidities or statin use. The risk of pneumonia was higher in elderly and male patients in the ND cohort.
Relation:	Current Medical Research and Opinion, v.35, n.6, pp.1033-1039
Appears in Collections:	[Dept. of Childhood Education and Nursery] Periodical Articles

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