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https://ir.cnu.edu.tw/handle/310902800/32560
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| 標題: | Associations between statins and coronary artery disease and stroke risks in patients with asthma-chronic obstructive pulmonary disease overlap syndrome: A time-dependent regression study |
| 作者: | Yeh, Jun-Jun(葉俊濬)
Lin, Cheng-Li
Hsu, Chung Y.
Shae, Zonyin
Kao, Chia-Hung |
| 貢獻者: | Chia Yi Christian Hosp, Ditmanson Med Fdn
Chia Nan Univ Pharm & Sci
China Med Univ
Mei Ho Univ
China Med Univ Hosp, Management Off Hlth Data
China Med Univ, Coll Med
China Med Univ, Coll Med, Grad Inst Biomed Sci
China Med Univ, Coll Med, Sch Med
Asia Univ, Dept Comp Sci & Informat Engn
China Med Univ Hosp, Dept Nucl Med
China Med Univ Hosp, PET Ctr
Asia Univ, Dept Bioinformat & Med Engn |
| 關鍵字: | Coronary artery disease
Stroke
Asthma-chronic obstructive pulmonary disease overlap syndrome |
| 日期: | 2019-04 |
| 上傳時間: | 2020-07-29 13:49:55 (UTC+8) |
| 出版者: | ELSEVIER IRELAND LTD |
| 摘要: | Backgound and aims: We aimed at determining the effects of statin use on coronary artery disease (CAD) and stroke risks in patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS). Methods: We retrospectively enrolled patients with ACOS treated with (N=916) and without (N=6338) statins. The cumulative incidence of CAD and stroke (ischemic and hemorrhagic) was analyzed through time-dependent Cox proportional regression. After adjustment for sex, age, comorbidities, inhaled corticosteroid steroid (ICS) use, and oral steroid (OS) use, we calculated the adjusted hazard ratios (aHRs) and their 95% confidence intervals (CIs) for CAD or stroke in the statin users (long-term [>600 days] and short-term [<= 600 days]) compared with the non-users. Results: Among the statin users, aHRs (95% CIs) for CAD and stroke were 0.50 (0.41-0.62) and 0.83 (0.63-1.09), respectively; moreover, aHRs were 0.30 (0.09-0.99) and 0.90 (0.68-1.20) for ischemic and hemorrhagic stroke, respectively. aHRs (95% CIs) for CAD and stroke were 0.58 (0.47-0.71) and 0.93 (0.70-1.23), respectively, in the short-term users and 0.23 (0.13-0.41) and 0.42 (0.19-0.89), respectively, in the long-term users. Conclusions: CAD risk was lower in all statin users, regardless of the duration of use, whereas ischemic stroke risk was lower only in the long-term statin users. No association was observed between hemorrhagic stroke risk and statin use. |
| 關聯: | Atherosclerosis, v.283, pp.61-68 |
| 顯示於類別: | [嬰幼兒保育系] 期刊論文
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