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    Title: Associations between statins and coronary artery disease and stroke risks in patients with asthma-chronic obstructive pulmonary disease overlap syndrome: A time-dependent regression study
    Authors: Yeh, Jun-Jun(葉俊濬)
    Lin, Cheng-Li
    Hsu, Chung Y.
    Shae, Zonyin
    Kao, Chia-Hung
    Contributors: Chia Yi Christian Hosp, Ditmanson Med Fdn
    Chia Nan Univ Pharm & Sci
    China Med Univ
    Mei Ho Univ
    China Med Univ Hosp, Management Off Hlth Data
    China Med Univ, Coll Med
    China Med Univ, Coll Med, Grad Inst Biomed Sci
    China Med Univ, Coll Med, Sch Med
    Asia Univ, Dept Comp Sci & Informat Engn
    China Med Univ Hosp, Dept Nucl Med
    China Med Univ Hosp, PET Ctr
    Asia Univ, Dept Bioinformat & Med Engn
    Keywords: Coronary artery disease
    Asthma-chronic obstructive pulmonary disease overlap syndrome
    Date: 2019-04
    Issue Date: 2020-07-29 13:49:55 (UTC+8)
    Abstract: Backgound and aims: We aimed at determining the effects of statin use on coronary artery disease (CAD) and stroke risks in patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS). Methods: We retrospectively enrolled patients with ACOS treated with (N=916) and without (N=6338) statins. The cumulative incidence of CAD and stroke (ischemic and hemorrhagic) was analyzed through time-dependent Cox proportional regression. After adjustment for sex, age, comorbidities, inhaled corticosteroid steroid (ICS) use, and oral steroid (OS) use, we calculated the adjusted hazard ratios (aHRs) and their 95% confidence intervals (CIs) for CAD or stroke in the statin users (long-term [>600 days] and short-term [<= 600 days]) compared with the non-users. Results: Among the statin users, aHRs (95% CIs) for CAD and stroke were 0.50 (0.41-0.62) and 0.83 (0.63-1.09), respectively; moreover, aHRs were 0.30 (0.09-0.99) and 0.90 (0.68-1.20) for ischemic and hemorrhagic stroke, respectively. aHRs (95% CIs) for CAD and stroke were 0.58 (0.47-0.71) and 0.93 (0.70-1.23), respectively, in the short-term users and 0.23 (0.13-0.41) and 0.42 (0.19-0.89), respectively, in the long-term users. Conclusions: CAD risk was lower in all statin users, regardless of the duration of use, whereas ischemic stroke risk was lower only in the long-term statin users. No association was observed between hemorrhagic stroke risk and statin use.
    Relation: Atherosclerosis, v.283, pp.61-68
    Appears in Collections:[Dept. of Childhood Education and Nursery] Periodical Articles

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