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    標題: Statin for Tuberculosis and Pneumonia in Patients with Asthma-Chronic Pulmonary Disease Overlap Syndrome: A Time-Dependent Population-Based Cohort Study
    作者: Yeh, Jun-Jun
    Lin, Cheng-Li
    Hsu, Chung-Y
    Shae, Zonyin
    Kao, Chia-Hung
    貢獻者: Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Family & Chest Med
    Chia Nan Univ Pharm & Sci, Dept Childhood Educ & Nursery
    China Med Univ, Dept Family Med
    Mei Ho Univ, Dept Nursing
    China Med Univ Hosp, Management Off Hlth Data
    China Med Univ, Coll Med
    China Med Univ, Coll Med, Grad Inst Biomed Sci
    China Med Univ, Coll Med, Sch Med
    Asia Univ, Dept Comp Sci & Informat Engn
    China Med Univ Hosp, Dept Nucl Med
    China Med Univ Hosp, PET Ctr
    Asia Univ, Dept Bioinformat & Med Engn
    關鍵字: tuberculosis
    asthma-chronic pulmonary disease overlap syndrome
    statins
    pneumonia
    日期: 2018-11
    上傳時間: 2019-11-15 15:46:31 (UTC+8)
    出版者: MDPI
    摘要: We investigated the effects of statins on tuberculosis (TB) and pneumonia risks in asthma-chronic pulmonary disease overlap syndrome (ACOS) patients. We extracted data of patients diagnosed as having ACOS during 2000-2010 from the Taiwan National Health Insurance Research Database and divided them into statin users and nonusers. All study participants were followed up from the index date until death, withdrawal from insurance, or TB and pneumonia occurred (31 December 2011). The cumulative TB and pneumonia incidence was analyzed using Cox proportional regression analysis with time-dependent variables. After adjustments for multiple confounding factors including age, sex, comorbidities, and use of medications [statins, inhaled corticosteroids (ICSs), or oral steroids (OSs)], statin use was associated with significantly lower TB [adjusted hazard ratio (aHR) 0.49, 95% confidence interval (CI) 0.34-0.70] and pneumonia (aHR 0.52, 95% CI 0.41-0.65) risks. Moreover, aHRs (95% CIs) for statins combined with ICSs and OSs were respectively 0.60 (0.31-1.16) and 0.58 (0.40-0.85) for TB and 0.61 (0.39-0.95) and 0.57 (0.45-0.74) for pneumonia. Thus, statin users had lower TB and pneumonia risks than did nonusers, regardless of age, sex, comorbidities, and ICS or OS use. Pneumonia risk was lower among users of statins combined with ICSs or Oss and TB risk was lower among the users of statins combined with OSs.
    關聯: Journal of Vector Ecology, v.7, n.11, 381
    顯示於類別:[嬰幼兒保育系] 期刊論文

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