Statin for Tuberculosis and Pneumonia in Patients with Asthma-Chronic Pulmonary Disease Overlap Syndrome: A Time-Dependent Population-Based Cohort Study

doi:10.3390/jcm7110381

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標題:	Statin for Tuberculosis and Pneumonia in Patients with Asthma-Chronic Pulmonary Disease Overlap Syndrome: A Time-Dependent Population-Based Cohort Study
作者:	Yeh, Jun-Jun Lin, Cheng-Li Hsu, Chung-Y Shae, Zonyin Kao, Chia-Hung
貢獻者:	Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Family & Chest Med Chia Nan Univ Pharm & Sci, Dept Childhood Educ & Nursery China Med Univ, Dept Family Med Mei Ho Univ, Dept Nursing China Med Univ Hosp, Management Off Hlth Data China Med Univ, Coll Med China Med Univ, Coll Med, Grad Inst Biomed Sci China Med Univ, Coll Med, Sch Med Asia Univ, Dept Comp Sci & Informat Engn China Med Univ Hosp, Dept Nucl Med China Med Univ Hosp, PET Ctr Asia Univ, Dept Bioinformat & Med Engn
關鍵字:	tuberculosis asthma-chronic pulmonary disease overlap syndrome statins pneumonia
日期:	2018-11
上傳時間:	2019-11-15 15:46:31 (UTC+8)
出版者:	MDPI
摘要:	We investigated the effects of statins on tuberculosis (TB) and pneumonia risks in asthma-chronic pulmonary disease overlap syndrome (ACOS) patients. We extracted data of patients diagnosed as having ACOS during 2000-2010 from the Taiwan National Health Insurance Research Database and divided them into statin users and nonusers. All study participants were followed up from the index date until death, withdrawal from insurance, or TB and pneumonia occurred (31 December 2011). The cumulative TB and pneumonia incidence was analyzed using Cox proportional regression analysis with time-dependent variables. After adjustments for multiple confounding factors including age, sex, comorbidities, and use of medications [statins, inhaled corticosteroids (ICSs), or oral steroids (OSs)], statin use was associated with significantly lower TB [adjusted hazard ratio (aHR) 0.49, 95% confidence interval (CI) 0.34-0.70] and pneumonia (aHR 0.52, 95% CI 0.41-0.65) risks. Moreover, aHRs (95% CIs) for statins combined with ICSs and OSs were respectively 0.60 (0.31-1.16) and 0.58 (0.40-0.85) for TB and 0.61 (0.39-0.95) and 0.57 (0.45-0.74) for pneumonia. Thus, statin users had lower TB and pneumonia risks than did nonusers, regardless of age, sex, comorbidities, and ICS or OS use. Pneumonia risk was lower among users of statins combined with ICSs or Oss and TB risk was lower among the users of statins combined with OSs.
關聯:	Journal of Vector Ecology, v.7, n.11, 381
显示于类别:	[嬰幼兒保育系] 期刊論文

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