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| 標題: | A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice |
| 作者: | Sheu, Joen-Rong
Chen, Zhih-Cherng
Jayakumar, Thanasekaran
Chou, Duen-Suey
Yen, Ting-Lin
Lee, Hsing-Ni
Pan, Szu-Han
Hsia, Chih-Hsuan
Yang, Chih-Hao
Hsieh, Cheng-Ying |
| 貢獻者: | Taipei Med Univ, Grad Inst Med Sci, Coll Med
Taipei Med Univ, Dept Pharmacol, Coll Med
Chi Mei Med Ctr, Dept Cardiol
Chia Nan Univ Pharm & Sci, Dept Pharm |
| 關鍵字: | Cerebral-Ischemia
In-Vivo
Antithrombotic Therapy
Photosensitizing Dye
Murine Macrophages
Reperfusion Injury
Oxidative Stress
Focal Ischemia
Rats
Cells |
| 日期: | 2017-02-06 |
| 上傳時間: | 2018-11-30 15:56:49 (UTC+8) |
| 出版者: | Nature Publishing Group |
| 摘要: | Thrombosis and stroke are major causes of disability and death worldwide. However, the regular antithrombotic drugs may have unsatisfactory results and side effects. Platonin, a cyanine photosensitizing dye, has been used to treat trauma, ulcers and some acute inflammation. Here, we explored the neuroprotective effects of platonin against middle cerebral artery occlusion (MCAO)-induced ischemic stroke in mice. Platonin(200 mu g/kg) substantially reduced cerebral infarct volume, brain edema, neuronal cell death and neurological deficit scores, and improved the MCAO-reduced locomotor activity and rotarod performance. Platonin(5-10 mu M) potently inhibited platelet aggregation and c-Jun NH2-terminal kinase (JNK) phosphorylation in collagen-activated platelets. The antiaggregation effect did not affect bleeding time but increased occlusion time in platonin(100 and 200 mu g/kg)-treated mice. Platonin(2-10 mu M) was potent in diminishing collagen-and Fenton reaction-induced (OH)-O-center dot formation. Platonin(5-10 mu M) also suppressed the expression of nitric oxide, inducible nitric oxide synthase, cyclooxygenase-2, interleukin-1 beta, and JNK phosphorylation in lipopolysaccharide-stimulated macrophages. MCAO-induced expression of 3-nitrotyrosine and Iba1 was apparently attenuated in platonin(200 mu g/kg)-treated mice. In conclusion, platonin exhibited remarkable neuroprotective properties against MCAO-induced ischemia in a mouse model through its antiaggregation, antiinflammatory and antiradical properties. The observed therapeutic efficacy of platonin may consider being a novel medcine against ischemic stroke. |
| 關聯: | Scientific Reports, v.7, pp.42277 |
| 顯示於類別: | [藥學系(所)] 期刊論文
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