A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice

doi:10.1038/srep42277

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 藥學系(所) > 期刊論文 > Item 310902800/31789

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/31789

標題:	A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice
作者:	Sheu, Joen-Rong Chen, Zhih-Cherng Jayakumar, Thanasekaran Chou, Duen-Suey Yen, Ting-Lin Lee, Hsing-Ni Pan, Szu-Han Hsia, Chih-Hsuan Yang, Chih-Hao Hsieh, Cheng-Ying
貢獻者:	Taipei Med Univ, Grad Inst Med Sci, Coll Med Taipei Med Univ, Dept Pharmacol, Coll Med Chi Mei Med Ctr, Dept Cardiol Chia Nan Univ Pharm & Sci, Dept Pharm
關鍵字:	Cerebral-Ischemia In-Vivo Antithrombotic Therapy Photosensitizing Dye Murine Macrophages Reperfusion Injury Oxidative Stress Focal Ischemia Rats Cells
日期:	2017-02-06
上傳時間:	2018-11-30 15:56:49 (UTC+8)
出版者:	Nature Publishing Group
摘要:	Thrombosis and stroke are major causes of disability and death worldwide. However, the regular antithrombotic drugs may have unsatisfactory results and side effects. Platonin, a cyanine photosensitizing dye, has been used to treat trauma, ulcers and some acute inflammation. Here, we explored the neuroprotective effects of platonin against middle cerebral artery occlusion (MCAO)-induced ischemic stroke in mice. Platonin(200 mu g/kg) substantially reduced cerebral infarct volume, brain edema, neuronal cell death and neurological deficit scores, and improved the MCAO-reduced locomotor activity and rotarod performance. Platonin(5-10 mu M) potently inhibited platelet aggregation and c-Jun NH2-terminal kinase (JNK) phosphorylation in collagen-activated platelets. The antiaggregation effect did not affect bleeding time but increased occlusion time in platonin(100 and 200 mu g/kg)-treated mice. Platonin(2-10 mu M) was potent in diminishing collagen-and Fenton reaction-induced (OH)-O-center dot formation. Platonin(5-10 mu M) also suppressed the expression of nitric oxide, inducible nitric oxide synthase, cyclooxygenase-2, interleukin-1 beta, and JNK phosphorylation in lipopolysaccharide-stimulated macrophages. MCAO-induced expression of 3-nitrotyrosine and Iba1 was apparently attenuated in platonin(200 mu g/kg)-treated mice. In conclusion, platonin exhibited remarkable neuroprotective properties against MCAO-induced ischemia in a mouse model through its antiaggregation, antiinflammatory and antiradical properties. The observed therapeutic efficacy of platonin may consider being a novel medcine against ischemic stroke.
關聯:	Scientific Reports, v.7, pp.42277
显示于类别:	[藥學系(所)] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
10.1038-srep42277.pdf		2182Kb	Adobe PDF	0	检视/开启
index.html		0Kb	HTML	1328	检视/开启

在CNU IR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....