資料載入中.....
|
請使用永久網址來引用或連結此文件:
https://ir.cnu.edu.tw/handle/310902800/31768
|
| 標題: | Evolution of hepatitis A virus seroprevalence among HIV-positive adults in Taiwan |
| 作者: | Lee, Yu-Lin
Lin, Kuan-Yin
Cheng, Chien-Yu
Li, Chia-Wen
Yang, Chia-Jui
Tsai, Mao-Song
Tang, Hung-Jen
Lin, Te-Yu
Wang, Ning-Chi
Lee, Yi-Chien
Lin, Shih-Ping
Huang, Yu-Shan
Sun, Hsin-Yun
Zhang, Jun-Yu
Ko, Wen-Chien
Cheng, Shu-Hsing
Lee, Yuan-Ti
Liu, Chun-Eng
Hung, Chien-Ching |
| 貢獻者: | Changhua Christian Hosp, Dept Internal Med
Natl Taiwan Univ Hosp, Dept Med, Jin Shan Branch
Minist Hlth & Welf, Dept Infect Dis,Taoyuan Gen Hosp
Natl Yang Ming Univ, Sch Publ Hlth
Natl Cheng Kung Univ Hosp, Dept Internal Med
Natl Cheng Kung Univ, Dept Med, Med Coll
Far Eastern Mem Hosp, Dept Internal Med
Natl Yang Ming Univ, Sch Med
Chi Mei Med Ctr, Dept Internal Med
Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
Triserv Gen Hosp, Dept Internal Med
Natl Def Med Ctr
Chia Yi Christian Hosp,Ditmanson Med Fdn, Dept Internal Med
Taichung Vet Gen Hosp, Dept Internal Med
Natl Taiwan Univ Hosp, Dept Internal Med, Hsin Chu Branch
Natl Taiwan Univ Hosp, Dept Internal Med
Natl Taiwan Univ, Coll Med
Chung Shan Med Univ, Sch Med
Chung Shan Med Univ Hosp, Dept Internal Med
Natl Taiwan Univ, Dept Parasitol, Coll Med |
| 關鍵字: | Harm Reduction Policy
Cost-Effectiveness
Universal Vaccination
Homosexual-Men
Drug-Users
Infection
Outbreak
Children
Sex
Population |
| 日期: | 2017-10-16 |
| 上傳時間: | 2018-11-30 15:55:59 (UTC+8) |
| 出版者: | Public Library Science |
| 摘要: | Objectives The study aimed to describe the seroprevalence of hepatitis A virus (HAV) in HIV-positive adult patients in Taiwan between 2012 and 2016 and to examine the evolution of HAV seroprevalence between 2004-2007 and 2012-2016. Methods Clinical information and data of anti-HAV antibody results were collected from 2,860 anti-retroviral-naive HIV-positive Taiwanese aged 18 years or older who initiated combination anti-retroviral therapy at 11 hospitals around Taiwan between 2012 and 2016 (2012-2016 cohort). A multivariate logistic regression model was applied to identify independent variables associated with HAV seropositivity. Comparisons of HAV seroprevalences and associated clinical characteristics were made between this 2012-2016 cohort and a previous cohort of 1580 HIV-positive patients in 2004-2007 (2004-2007 cohort). Results Of the 2,860 HIV-positive patients between 2012 and 2016, the overall HAV seropositivity rate was 21.2% (605/2860), which was independently associated with an older age (adjusted odds ratio [AOR], per 1-year increase, 1.13; 95% confidence interval [95% CI], 1.11-1.15) and co-infection with hepatitis B virus (AOR 1.44; 95% CI, 1.08-1.93). Residence inSouthern Taiwan (AOR 0.49; 95% CI, 0.34-0.72) was inversely associated with HAV seropositivity. The overall HAV seroprevalence in the 2012-2016 cohort was significantly lower than that in the 2004-2007 cohort (21.2% vs 60.9%, p<0.01). The decreases of HAV seropositivity rate were observed in nearly every age-matched group, which suggested the cohort effect on HAV seroepidemiology. However, among individuals aged 25 years or younger, the HAV seropositivity rate increased from 3.8% (2/52) in the 2004-2007 cohort to 8.5% (50/587) in the 2012-2016 cohort, with 95.4% (560/587) being MSM in this age group of the latter cohort. Conclusions HAV seroprevalence has decreased with time among HIV-positive adults in Taiwan. The cohort effect has increased the number of young HIV-positive patients that are susceptible to HAV infection in a country without nationwide childhood vaccination program against HAV. |
| 關聯: | Plos One, v.12, n.10, e0186338 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
|
文件中的檔案:
| 檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
|---|
| index.html | | 0Kb | HTML | 1237 | 檢視/開啟 | | journal.pone.0186338.pdf | | 914Kb | Adobe PDF | 279 | 檢視/開啟 |
|
在CNU IR中所有的資料項目都受到原著作權保護.
|
