Evolution of hepatitis A virus seroprevalence among HIV-positive adults in Taiwan

doi:10.1371/journal.pone.0186338

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標題:	Evolution of hepatitis A virus seroprevalence among HIV-positive adults in Taiwan
作者:	Lee, Yu-Lin Lin, Kuan-Yin Cheng, Chien-Yu Li, Chia-Wen Yang, Chia-Jui Tsai, Mao-Song Tang, Hung-Jen Lin, Te-Yu Wang, Ning-Chi Lee, Yi-Chien Lin, Shih-Ping Huang, Yu-Shan Sun, Hsin-Yun Zhang, Jun-Yu Ko, Wen-Chien Cheng, Shu-Hsing Lee, Yuan-Ti Liu, Chun-Eng Hung, Chien-Ching
貢獻者:	Changhua Christian Hosp, Dept Internal Med Natl Taiwan Univ Hosp, Dept Med, Jin Shan Branch Minist Hlth & Welf, Dept Infect Dis,Taoyuan Gen Hosp Natl Yang Ming Univ, Sch Publ Hlth Natl Cheng Kung Univ Hosp, Dept Internal Med Natl Cheng Kung Univ, Dept Med, Med Coll Far Eastern Mem Hosp, Dept Internal Med Natl Yang Ming Univ, Sch Med Chi Mei Med Ctr, Dept Internal Med Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Triserv Gen Hosp, Dept Internal Med Natl Def Med Ctr Chia Yi Christian Hosp,Ditmanson Med Fdn, Dept Internal Med Taichung Vet Gen Hosp, Dept Internal Med Natl Taiwan Univ Hosp, Dept Internal Med, Hsin Chu Branch Natl Taiwan Univ Hosp, Dept Internal Med Natl Taiwan Univ, Coll Med Chung Shan Med Univ, Sch Med Chung Shan Med Univ Hosp, Dept Internal Med Natl Taiwan Univ, Dept Parasitol, Coll Med
關鍵字:	Harm Reduction Policy Cost-Effectiveness Universal Vaccination Homosexual-Men Drug-Users Infection Outbreak Children Sex Population
日期:	2017-10-16
上傳時間:	2018-11-30 15:55:59 (UTC+8)
出版者:	Public Library Science
摘要:	Objectives The study aimed to describe the seroprevalence of hepatitis A virus (HAV) in HIV-positive adult patients in Taiwan between 2012 and 2016 and to examine the evolution of HAV seroprevalence between 2004-2007 and 2012-2016. Methods Clinical information and data of anti-HAV antibody results were collected from 2,860 anti-retroviral-naive HIV-positive Taiwanese aged 18 years or older who initiated combination anti-retroviral therapy at 11 hospitals around Taiwan between 2012 and 2016 (2012-2016 cohort). A multivariate logistic regression model was applied to identify independent variables associated with HAV seropositivity. Comparisons of HAV seroprevalences and associated clinical characteristics were made between this 2012-2016 cohort and a previous cohort of 1580 HIV-positive patients in 2004-2007 (2004-2007 cohort). Results Of the 2,860 HIV-positive patients between 2012 and 2016, the overall HAV seropositivity rate was 21.2% (605/2860), which was independently associated with an older age (adjusted odds ratio [AOR], per 1-year increase, 1.13; 95% confidence interval [95% CI], 1.11-1.15) and co-infection with hepatitis B virus (AOR 1.44; 95% CI, 1.08-1.93). Residence inSouthern Taiwan (AOR 0.49; 95% CI, 0.34-0.72) was inversely associated with HAV seropositivity. The overall HAV seroprevalence in the 2012-2016 cohort was significantly lower than that in the 2004-2007 cohort (21.2% vs 60.9%, p<0.01). The decreases of HAV seropositivity rate were observed in nearly every age-matched group, which suggested the cohort effect on HAV seroepidemiology. However, among individuals aged 25 years or younger, the HAV seropositivity rate increased from 3.8% (2/52) in the 2004-2007 cohort to 8.5% (50/587) in the 2012-2016 cohort, with 95.4% (560/587) being MSM in this age group of the latter cohort. Conclusions HAV seroprevalence has decreased with time among HIV-positive adults in Taiwan. The cohort effect has increased the number of young HIV-positive patients that are susceptible to HAV infection in a country without nationwide childhood vaccination program against HAV.
關聯:	Plos One, v.12, n.10, e0186338
显示于类别:	[保健營養系(所) ] 期刊論文

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