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    Title: Evolution of hepatitis A virus seroprevalence among HIV-positive adults in Taiwan
    Authors: Lee, Yu-Lin
    Lin, Kuan-Yin
    Cheng, Chien-Yu
    Li, Chia-Wen
    Yang, Chia-Jui
    Tsai, Mao-Song
    Tang, Hung-Jen
    Lin, Te-Yu
    Wang, Ning-Chi
    Lee, Yi-Chien
    Lin, Shih-Ping
    Huang, Yu-Shan
    Sun, Hsin-Yun
    Zhang, Jun-Yu
    Ko, Wen-Chien
    Cheng, Shu-Hsing
    Lee, Yuan-Ti
    Liu, Chun-Eng
    Hung, Chien-Ching
    Contributors: Changhua Christian Hosp, Dept Internal Med
    Natl Taiwan Univ Hosp, Dept Med, Jin Shan Branch
    Minist Hlth & Welf, Dept Infect Dis,Taoyuan Gen Hosp
    Natl Yang Ming Univ, Sch Publ Hlth
    Natl Cheng Kung Univ Hosp, Dept Internal Med
    Natl Cheng Kung Univ, Dept Med, Med Coll
    Far Eastern Mem Hosp, Dept Internal Med
    Natl Yang Ming Univ, Sch Med
    Chi Mei Med Ctr, Dept Internal Med
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Triserv Gen Hosp, Dept Internal Med
    Natl Def Med Ctr
    Chia Yi Christian Hosp,Ditmanson Med Fdn, Dept Internal Med
    Taichung Vet Gen Hosp, Dept Internal Med
    Natl Taiwan Univ Hosp, Dept Internal Med, Hsin Chu Branch
    Natl Taiwan Univ Hosp, Dept Internal Med
    Natl Taiwan Univ, Coll Med
    Chung Shan Med Univ, Sch Med
    Chung Shan Med Univ Hosp, Dept Internal Med
    Natl Taiwan Univ, Dept Parasitol, Coll Med
    Keywords: Harm Reduction Policy
    Universal Vaccination
    Date: 2017-10-16
    Issue Date: 2018-11-30 15:55:59 (UTC+8)
    Publisher: Public Library Science
    Abstract: Objectives The study aimed to describe the seroprevalence of hepatitis A virus (HAV) in HIV-positive adult patients in Taiwan between 2012 and 2016 and to examine the evolution of HAV seroprevalence between 2004-2007 and 2012-2016. Methods Clinical information and data of anti-HAV antibody results were collected from 2,860 anti-retroviral-naive HIV-positive Taiwanese aged 18 years or older who initiated combination anti-retroviral therapy at 11 hospitals around Taiwan between 2012 and 2016 (2012-2016 cohort). A multivariate logistic regression model was applied to identify independent variables associated with HAV seropositivity. Comparisons of HAV seroprevalences and associated clinical characteristics were made between this 2012-2016 cohort and a previous cohort of 1580 HIV-positive patients in 2004-2007 (2004-2007 cohort). Results Of the 2,860 HIV-positive patients between 2012 and 2016, the overall HAV seropositivity rate was 21.2% (605/2860), which was independently associated with an older age (adjusted odds ratio [AOR], per 1-year increase, 1.13; 95% confidence interval [95% CI], 1.11-1.15) and co-infection with hepatitis B virus (AOR 1.44; 95% CI, 1.08-1.93). Residence inSouthern Taiwan (AOR 0.49; 95% CI, 0.34-0.72) was inversely associated with HAV seropositivity. The overall HAV seroprevalence in the 2012-2016 cohort was significantly lower than that in the 2004-2007 cohort (21.2% vs 60.9%, p<0.01). The decreases of HAV seropositivity rate were observed in nearly every age-matched group, which suggested the cohort effect on HAV seroepidemiology. However, among individuals aged 25 years or younger, the HAV seropositivity rate increased from 3.8% (2/52) in the 2004-2007 cohort to 8.5% (50/587) in the 2012-2016 cohort, with 95.4% (560/587) being MSM in this age group of the latter cohort. Conclusions HAV seroprevalence has decreased with time among HIV-positive adults in Taiwan. The cohort effect has increased the number of young HIV-positive patients that are susceptible to HAV infection in a country without nationwide childhood vaccination program against HAV.
    Relation: Plos One, v.12, n.10, e0186338
    Appears in Collections:[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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