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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/30998


    標題: Reversal of ethanol-induced hepatotoxicity by cinnamic and syringic acids in mice
    作者: Yan, Sheng-lei
    Wang, Zhi-hong
    Yen, Hsiu-fang
    Lee, Yi-ju
    Yin, Mei-chin
    貢獻者: Chang Bing Show Chwan Mem Hosp, Div Gastroenterol, Dept Internal Med, Lukang
    China Med Univ, Dept Nutr
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Chung Shan Med Univ Hosp, Dept Pathol
    Asia Univ, Dept Hlth & Nutr Biotechnol
    關鍵字: Ethanol
    Hepatoxicity
    Cinnamic acid
    Syringic acid
    Nrf2
    CYP2E1
    日期: 2016-12
    上傳時間: 2018-01-18 11:39:32 (UTC+8)
    出版者: Pergamon-Elsevier Science Ltd
    摘要: Ethanol was used to induce acute hepatotoxicity in mice. Effects of cinnamic acid (CA) and syringic acid (SA) post-intake for hepatic recovery from alcoholic injury was investigated. Ethanol treated mice were supplied by CA or SA at 40 or 80 mg/kg BW/day for 5 days. Results showed that ethanol stimulated,, protein expression of CYP2E1, p47(phox), gp91(phox) , cyclooxygenase-2 and nuclear factor kappa B in liver. CA or SA post-intake restricted hepatic expression of these molecules. Ethanol suppressed nuclear factor erythroid 2-related factor (Nrf2) expression, and CA or SA enhanced Nrf2 expression in cytosolic and nuclear fractions. Ethanol increased the release of reactive oxygen species, oxidized glutathione, interleukin-6, tumor necrosis factor-alpha, nitric acid and prostaglandin E-2. CA or SA lowered hepatic production of these oxidative and inflammatory factors. Histological data revealed that ethanol administration caused obvious foci of inflammatory cell infiltration, and CA or SA post-intake improved hepatic inflammatory infiltration. These findings support that cinnamic acid and syringic acid are potent nutraceutical agents for acute alcoholic liver disease therapy. However, potential additive or synergistic benefits of cinnamic and syringic acids against ethanol-induced hepatotoxicity need to be investigated. (C) 2016 Elsevier Ltd. All rights reserved.
    關聯: Food and Chemical Toxicology, v.98 Part.B, pp.119-126
    Appears in Collections:[保健營養系(所) ] 期刊論文

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