Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/30998
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 17776/20117 (88%)
Visitors : 10938462      Online Users : 433
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item:

    Title: Reversal of ethanol-induced hepatotoxicity by cinnamic and syringic acids in mice
    Authors: Yan, Sheng-lei
    Wang, Zhi-hong
    Yen, Hsiu-fang
    Lee, Yi-ju
    Yin, Mei-chin
    Contributors: Chang Bing Show Chwan Mem Hosp, Div Gastroenterol, Dept Internal Med, Lukang
    China Med Univ, Dept Nutr
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Chung Shan Med Univ Hosp, Dept Pathol
    Asia Univ, Dept Hlth & Nutr Biotechnol
    Keywords: Ethanol
    Cinnamic acid
    Syringic acid
    Date: 2016-12
    Issue Date: 2018-01-18 11:39:32 (UTC+8)
    Publisher: Pergamon-Elsevier Science Ltd
    Abstract: Ethanol was used to induce acute hepatotoxicity in mice. Effects of cinnamic acid (CA) and syringic acid (SA) post-intake for hepatic recovery from alcoholic injury was investigated. Ethanol treated mice were supplied by CA or SA at 40 or 80 mg/kg BW/day for 5 days. Results showed that ethanol stimulated,, protein expression of CYP2E1, p47(phox), gp91(phox) , cyclooxygenase-2 and nuclear factor kappa B in liver. CA or SA post-intake restricted hepatic expression of these molecules. Ethanol suppressed nuclear factor erythroid 2-related factor (Nrf2) expression, and CA or SA enhanced Nrf2 expression in cytosolic and nuclear fractions. Ethanol increased the release of reactive oxygen species, oxidized glutathione, interleukin-6, tumor necrosis factor-alpha, nitric acid and prostaglandin E-2. CA or SA lowered hepatic production of these oxidative and inflammatory factors. Histological data revealed that ethanol administration caused obvious foci of inflammatory cell infiltration, and CA or SA post-intake improved hepatic inflammatory infiltration. These findings support that cinnamic acid and syringic acid are potent nutraceutical agents for acute alcoholic liver disease therapy. However, potential additive or synergistic benefits of cinnamic and syringic acids against ethanol-induced hepatotoxicity need to be investigated. (C) 2016 Elsevier Ltd. All rights reserved.
    Relation: Food and Chemical Toxicology, v.98 Part.B, pp.119-126
    Appears in Collections:[Dept. of Health and Nutrition (including master's program)] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    30998.pdf2168KbAdobe PDF0View/Open

    All items in CNU IR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback