Reversal of ethanol-induced hepatotoxicity by cinnamic and syringic acids in mice

doi:10.1016/j.fct.2016.10.025

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標題:	Reversal of ethanol-induced hepatotoxicity by cinnamic and syringic acids in mice
作者:	Yan, Sheng-lei Wang, Zhi-hong Yen, Hsiu-fang Lee, Yi-ju Yin, Mei-chin
貢獻者:	Chang Bing Show Chwan Mem Hosp, Div Gastroenterol, Dept Internal Med, Lukang China Med Univ, Dept Nutr Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Chung Shan Med Univ Hosp, Dept Pathol Asia Univ, Dept Hlth & Nutr Biotechnol
關鍵字:	Ethanol Hepatoxicity Cinnamic acid Syringic acid Nrf2 CYP2E1
日期:	2016-12
上傳時間:	2018-01-18 11:39:32 (UTC+8)
出版者:	Pergamon-Elsevier Science Ltd
摘要:	Ethanol was used to induce acute hepatotoxicity in mice. Effects of cinnamic acid (CA) and syringic acid (SA) post-intake for hepatic recovery from alcoholic injury was investigated. Ethanol treated mice were supplied by CA or SA at 40 or 80 mg/kg BW/day for 5 days. Results showed that ethanol stimulated,, protein expression of CYP2E1, p47(phox), gp91(phox) , cyclooxygenase-2 and nuclear factor kappa B in liver. CA or SA post-intake restricted hepatic expression of these molecules. Ethanol suppressed nuclear factor erythroid 2-related factor (Nrf2) expression, and CA or SA enhanced Nrf2 expression in cytosolic and nuclear fractions. Ethanol increased the release of reactive oxygen species, oxidized glutathione, interleukin-6, tumor necrosis factor-alpha, nitric acid and prostaglandin E-2. CA or SA lowered hepatic production of these oxidative and inflammatory factors. Histological data revealed that ethanol administration caused obvious foci of inflammatory cell infiltration, and CA or SA post-intake improved hepatic inflammatory infiltration. These findings support that cinnamic acid and syringic acid are potent nutraceutical agents for acute alcoholic liver disease therapy. However, potential additive or synergistic benefits of cinnamic and syringic acids against ethanol-induced hepatotoxicity need to be investigated. (C) 2016 Elsevier Ltd. All rights reserved.
關聯:	Food and Chemical Toxicology, v.98 Part.B, pp.119-126
显示于类别:	[保健營養系(所) ] 期刊論文

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