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https://ir.cnu.edu.tw/handle/310902800/30943
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| 標題: | The Inhibitory Mechanisms Study of 5,6,4 '-Trihydroxy-7,3 '-Dimethoxyflavone against the LPS-Induced Macrophage Inflammatory Responses through the Antioxidant Ability |
| 作者: | Wang, Shih-Hao
Liang, Chia-Hua
Liang, Fong-Pin
Ding, Hsiou-Yu
Lin, Shiuan-Pey
Huang, Guan-Jhong
Lin, Wen-Chuan
Juang, Shin-Hun |
| 貢獻者: | China Med Univ, Sch Pharm
Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
Tajen Univ, Dept Pharm
Chia Nan Univ Pharm & Sci, Inst Cosmet Sci
China Med Univ, Dept Chinese Pharmaceut Sci & Chinese Med Resourc |
| 關鍵字: | Anisomeles ovata
5,6,4'-trihydroxy-7
3-dimethoxyflavone
anti-inflammatory
anti-oxidant
reactive oxygen species
mapks |
| 日期: | 2016-02 |
| 上傳時間: | 2018-01-18 11:38:24 (UTC+8) |
| 出版者: | Mdpi Ag |
| 摘要: | The whole plant of Anisomeles ovata has been widely used in Taiwan for treating inflammation-related skin and liver diseases, however, the detailed pharmacology mechanisms have yet to be elucidated. In the present study, one of the major components, 5,6,4-trihydroxy-7,3-dimethoxyflavone (5-TDMF), was purified from a methanol extract of Anisomeles ovata. A pharmacological study of this compound suggests that 5-TDMF possesses potent free radical scavenging activity both in vitro and ex vivo. Furthermore, 5-TDMF reduces nitric oxide and pro-inflammatory cytokine production in LPC-treated RAW 264.7 cells through the attenuation of nitric oxide synthase and cyclooxygenase-2. Additional experiments suggest that of 5-TDMF interferes with nuclear factor-B translocation and mitogen-activated protein kinase pathways. These results identify 5-TDMF as an anti-oxidant and anti-inflammatory compound, explain the pharmacologic function of Anisomeles ovata and suggest its great potential as a new anti-inflammatory remedy. |
| 關聯: | Molecules, v.21 n.2, 136 |
| 顯示於類別: | [化妝品應用與管理系(所)] 期刊論文
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