The Inhibitory Mechanisms Study of 5,6,4 '-Trihydroxy-7,3 '-Dimethoxyflavone against the LPS-Induced Macrophage Inflammatory Responses through the Antioxidant Ability

doi:10.3390/molecules21020136

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/30943

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/30943

Title:	The Inhibitory Mechanisms Study of 5,6,4 '-Trihydroxy-7,3 '-Dimethoxyflavone against the LPS-Induced Macrophage Inflammatory Responses through the Antioxidant Ability
Authors:	Wang, Shih-Hao Liang, Chia-Hua Liang, Fong-Pin Ding, Hsiou-Yu Lin, Shiuan-Pey Huang, Guan-Jhong Lin, Wen-Chuan Juang, Shin-Hun
Contributors:	China Med Univ, Sch Pharm Chia Nan Univ Pharm & Sci, Dept Cosmet Sci Tajen Univ, Dept Pharm Chia Nan Univ Pharm & Sci, Inst Cosmet Sci China Med Univ, Dept Chinese Pharmaceut Sci & Chinese Med Resourc
Keywords:	Anisomeles ovata 5,6,4'-trihydroxy-7 3-dimethoxyflavone anti-inflammatory anti-oxidant reactive oxygen species mapks
Date:	2016-02
Issue Date:	2018-01-18 11:38:24 (UTC+8)
Publisher:	Mdpi Ag
Abstract:	The whole plant of Anisomeles ovata has been widely used in Taiwan for treating inflammation-related skin and liver diseases, however, the detailed pharmacology mechanisms have yet to be elucidated. In the present study, one of the major components, 5,6,4-trihydroxy-7,3-dimethoxyflavone (5-TDMF), was purified from a methanol extract of Anisomeles ovata. A pharmacological study of this compound suggests that 5-TDMF possesses potent free radical scavenging activity both in vitro and ex vivo. Furthermore, 5-TDMF reduces nitric oxide and pro-inflammatory cytokine production in LPC-treated RAW 264.7 cells through the attenuation of nitric oxide synthase and cyclooxygenase-2. Additional experiments suggest that of 5-TDMF interferes with nuclear factor-B translocation and mitogen-activated protein kinase pathways. These results identify 5-TDMF as an anti-oxidant and anti-inflammatory compound, explain the pharmacologic function of Anisomeles ovata and suggest its great potential as a new anti-inflammatory remedy.
Relation:	Molecules, v.21 n.2, 136
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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