The Inhibitory Mechanisms Study of 5,6,4 '-Trihydroxy-7,3 '-Dimethoxyflavone against the LPS-Induced Macrophage Inflammatory Responses through the Antioxidant Ability

doi:10.3390/molecules21020136

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 期刊論文 > Item 310902800/30943

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標題:	The Inhibitory Mechanisms Study of 5,6,4 '-Trihydroxy-7,3 '-Dimethoxyflavone against the LPS-Induced Macrophage Inflammatory Responses through the Antioxidant Ability
作者:	Wang, Shih-Hao Liang, Chia-Hua Liang, Fong-Pin Ding, Hsiou-Yu Lin, Shiuan-Pey Huang, Guan-Jhong Lin, Wen-Chuan Juang, Shin-Hun
貢獻者:	China Med Univ, Sch Pharm Chia Nan Univ Pharm & Sci, Dept Cosmet Sci Tajen Univ, Dept Pharm Chia Nan Univ Pharm & Sci, Inst Cosmet Sci China Med Univ, Dept Chinese Pharmaceut Sci & Chinese Med Resourc
關鍵字:	Anisomeles ovata 5,6,4'-trihydroxy-7 3-dimethoxyflavone anti-inflammatory anti-oxidant reactive oxygen species mapks
日期:	2016-02
上傳時間:	2018-01-18 11:38:24 (UTC+8)
出版者:	Mdpi Ag
摘要:	The whole plant of Anisomeles ovata has been widely used in Taiwan for treating inflammation-related skin and liver diseases, however, the detailed pharmacology mechanisms have yet to be elucidated. In the present study, one of the major components, 5,6,4-trihydroxy-7,3-dimethoxyflavone (5-TDMF), was purified from a methanol extract of Anisomeles ovata. A pharmacological study of this compound suggests that 5-TDMF possesses potent free radical scavenging activity both in vitro and ex vivo. Furthermore, 5-TDMF reduces nitric oxide and pro-inflammatory cytokine production in LPC-treated RAW 264.7 cells through the attenuation of nitric oxide synthase and cyclooxygenase-2. Additional experiments suggest that of 5-TDMF interferes with nuclear factor-B translocation and mitogen-activated protein kinase pathways. These results identify 5-TDMF as an anti-oxidant and anti-inflammatory compound, explain the pharmacologic function of Anisomeles ovata and suggest its great potential as a new anti-inflammatory remedy.
關聯:	Molecules, v.21 n.2, 136
显示于类别:	[化妝品應用與管理系(所)] 期刊論文

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