English  |  正體中文  |  简体中文  |  Items with full text/Total items : 17744/20032 (89%)
Visitors : 7371039      Online Users : 273
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/30191

    標題: 以物理性、生物性因子誘導及化學半合成方法之紅麴二次代謝物的化粧品功能性分析 ─ 子計畫二:以3D QSAR與半合成方法由紅麴色素開發新穎性之黑色素生成抑制劑
    3D QSAR and semisynthetic Approaches to Develop Novel Pigments from Monascus sp. as Melanogenesis Inhibitors
    作者: 李冠漢
    貢獻者: 藥學系
    日期: 2016
    上傳時間: 2017-02-16 16:09:14 (UTC+8)
    摘要: Filamentous fungi are known to be prolific producers of secondary metabolites, such as penicillin, lovastatin, and cyclosporine, and are an important resource for discovering small molecules of pharmaceutical and industrial value. Monascus spp. produced several well-known polyketides such as monacolin K, citrinin, and azaphilone pigments. Azaphilone pigments are a class of fungal metabolites characterized by a highly oxygenated pyrano-qunone bicyclic core and exhibiting a broad range of bioactivities. In this study, the orange pigments will be transformed into red pigments by replacing the oxygen moiety of orange pigments with various nitrogen-containing derivatives. The optimal side chain will be selected by using 3D QSAR approaches, such as pharmacophare development and molecular simulation. The amino acid and amino alcohol derivatives will be tested as the inhibitors of melanogenesis for novel cosmeceuticals.
    關聯: 計畫編號:CN10501;計畫年度:105
    Appears in Collections:[藥學系(所)] 校內計畫

    Files in This Item:

    File Description SizeFormat
    CN10501.pdf321KbAdobe PDF346View/Open

    All items in CNU IR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback