以物理性、生物性因子誘導及化學半合成方法之紅麴二次代謝物的化粧品功能性分析 ─ 子計畫二：以3D QSAR與半合成方法由紅麴色素開發新穎性之黑色素生成抑制劑

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Title:	以物理性、生物性因子誘導及化學半合成方法之紅麴二次代謝物的化粧品功能性分析 ─ 子計畫二：以3D QSAR與半合成方法由紅麴色素開發新穎性之黑色素生成抑制劑 3D QSAR and semisynthetic Approaches to Develop Novel Pigments from Monascus sp. as Melanogenesis Inhibitors
Authors:	李冠漢
Contributors:	藥學系
Date:	2016
Issue Date:	2017-02-16 16:09:14 (UTC+8)
Abstract:	Filamentous fungi are known to be prolific producers of secondary metabolites, such as penicillin, lovastatin, and cyclosporine, and are an important resource for discovering small molecules of pharmaceutical and industrial value. Monascus spp. produced several well-known polyketides such as monacolin K, citrinin, and azaphilone pigments. Azaphilone pigments are a class of fungal metabolites characterized by a highly oxygenated pyrano-qunone bicyclic core and exhibiting a broad range of bioactivities. In this study, the orange pigments will be transformed into red pigments by replacing the oxygen moiety of orange pigments with various nitrogen-containing derivatives. The optimal side chain will be selected by using 3D QSAR approaches, such as pharmacophare development and molecular simulation. The amino acid and amino alcohol derivatives will be tested as the inhibitors of melanogenesis for novel cosmeceuticals.
Relation:	計畫編號：CN10501；計畫年度：105
Appears in Collections:	[Dept. of Pharmacy] CNU Project

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