以物理性、生物性因子誘導及化學半合成方法之紅麴二次代謝物的化粧品功能性分析 ─ 子計畫二：以3D QSAR與半合成方法由紅麴色素開發新穎性之黑色素生成抑制劑

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 藥學系(所) > 校內計畫 > Item 310902800/30191

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/30191

標題:	以物理性、生物性因子誘導及化學半合成方法之紅麴二次代謝物的化粧品功能性分析 ─ 子計畫二：以3D QSAR與半合成方法由紅麴色素開發新穎性之黑色素生成抑制劑 3D QSAR and semisynthetic Approaches to Develop Novel Pigments from Monascus sp. as Melanogenesis Inhibitors
作者:	李冠漢
貢獻者:	藥學系
日期:	2016
上傳時間:	2017-02-16 16:09:14 (UTC+8)
摘要:	Filamentous fungi are known to be prolific producers of secondary metabolites, such as penicillin, lovastatin, and cyclosporine, and are an important resource for discovering small molecules of pharmaceutical and industrial value. Monascus spp. produced several well-known polyketides such as monacolin K, citrinin, and azaphilone pigments. Azaphilone pigments are a class of fungal metabolites characterized by a highly oxygenated pyrano-qunone bicyclic core and exhibiting a broad range of bioactivities. In this study, the orange pigments will be transformed into red pigments by replacing the oxygen moiety of orange pigments with various nitrogen-containing derivatives. The optimal side chain will be selected by using 3D QSAR approaches, such as pharmacophare development and molecular simulation. The amino acid and amino alcohol derivatives will be tested as the inhibitors of melanogenesis for novel cosmeceuticals.
關聯:	計畫編號：CN10501；計畫年度：105
显示于类别:	[藥學系(所)] 校內計畫

文件中的档案:

档案	描述	大小	格式	浏览次数
CN10501.pdf		321Kb	Adobe PDF	651	检视/开启

在CNU IR中所有的数据项都受到原著作权保护.

TAIR相关文章