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https://ir.cnu.edu.tw/handle/310902800/28698
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| 標題: | Simultaneous Determination of Antidiabetic Thiazolidinediones Using Flow Through Voltammetric Sensor |
| 作者: | Wang, Lai-Hao
Song, Yan-Lin |
| 貢獻者: | 醫藥化學系 |
| 關鍵字: | Voltammetric sensor
thiazolidine-2, 4-diones (TZDs)
antidiabetic drugs |
| 日期: | 2014 |
| 上傳時間: | 2015-05-06 21:25:35 (UTC+8) |
| 出版者: | Bentham Science Publ Ltd |
| 摘要: | We developed a method that uses flow through voltammetric sensor to quantitatively determine thiazolidine-2, 4-diones (TZDs) derivatives which are pioglitazone, rosiglitazone and troglitazone. The method uses a gold electrode. The dynamic range for determining thiazolidine-2, 4-diones (TZDs) is extended by more than two orders of magnitude. The quantification limits are 0.10, 23, 15, 0.005 ng for thiazolidine-2, 4-dione, pioglitazone, rosiglitazone and troglitazone, respectively. The method can be applied to the quantitatively determining pioglitazone and rosiglitazone in antidiabetic drugs. Findings using high-performance liquid chromatography with a flow-through voltammetric detector and ultraviolet detector are comparable. |
| 關聯: | Current Pharmaceutical Analysis, v.10 n.4, pp.239-245 |
| 顯示於類別: | [食藥產業暨檢測科技系(含五專)] 期刊論文
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