We developed a method that uses flow through voltammetric sensor to quantitatively determine thiazolidine-2, 4-diones (TZDs) derivatives which are pioglitazone, rosiglitazone and troglitazone. The method uses a gold electrode. The dynamic range for determining thiazolidine-2, 4-diones (TZDs) is extended by more than two orders of magnitude. The quantification limits are 0.10, 23, 15, 0.005 ng for thiazolidine-2, 4-dione, pioglitazone, rosiglitazone and troglitazone, respectively. The method can be applied to the quantitatively determining pioglitazone and rosiglitazone in antidiabetic drugs. Findings using high-performance liquid chromatography with a flow-through voltammetric detector and ultraviolet detector are comparable.
關聯:
Current Pharmaceutical Analysis, v.10 n.4, pp.239-245
