Simultaneous Determination of Antidiabetic Thiazolidinediones Using Flow Through Voltammetric Sensor

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Title:	Simultaneous Determination of Antidiabetic Thiazolidinediones Using Flow Through Voltammetric Sensor
Authors:	Wang, Lai-Hao Song, Yan-Lin
Contributors:	醫藥化學系
Keywords:	Voltammetric sensor thiazolidine-2, 4-diones (TZDs) antidiabetic drugs
Date:	2014
Issue Date:	2015-05-06 21:25:35 (UTC+8)
Publisher:	Bentham Science Publ Ltd
Abstract:	We developed a method that uses flow through voltammetric sensor to quantitatively determine thiazolidine-2, 4-diones (TZDs) derivatives which are pioglitazone, rosiglitazone and troglitazone. The method uses a gold electrode. The dynamic range for determining thiazolidine-2, 4-diones (TZDs) is extended by more than two orders of magnitude. The quantification limits are 0.10, 23, 15, 0.005 ng for thiazolidine-2, 4-dione, pioglitazone, rosiglitazone and troglitazone, respectively. The method can be applied to the quantitatively determining pioglitazone and rosiglitazone in antidiabetic drugs. Findings using high-performance liquid chromatography with a flow-through voltammetric detector and ultraviolet detector are comparable.
Relation:	Current Pharmaceutical Analysis, v.10 n.4, pp.239-245
Appears in Collections:	[Dept. of Food & Drug Industry and Inspective Technology] Periodical Articles

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