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| 標題: | Intrathecal orphenadrine elicits spinal block in the rat |
| 作者: | Chen, Yu-Wen
Tzeng, Jann-Inn
Chen, Yu-Chung
Hung, Ching-Hsia
Wang, Jhi-Joung |
| 貢獻者: | 食品科技系 |
| 關鍵字: | Orphenadrine
Lidocaine
Spinal anesthesia
Motor function
Proptioception
Nociception |
| 日期: | 2014-11 |
| 上傳時間: | 2015-05-06 21:22:22 (UTC+8) |
| 出版者: | Elsevier Science Bv |
| 摘要: | The purpose of this study was to estimate the local anesthetic effect of orphenadrine, an anti-muscarinic agent, in spinal anesthesia and its comparison with the local anesthetic lidocaine. After the rat was injected intrathecally, the spinal block of orphenadrine and lidocaine was constructed in a dosage-dependent fashion. The potency and duration of spinal anesthesia with orphenadrine were compared with that of lidocaine. Our data demonstrated that orphenadrine and lidocaine elicited dose-dependent spinal blockades on the motor function, sensory, and proprioception. On the 50% effective dose (ED50) basis, the ranks of potency in motor function, nociception, and proprioception were orphenadrine > lidocaine (P < 0.01). At equipotent doses (ED25, ED50, ED75), the block duration elicited by orphenadrine was greater than that elicited by lidocaine (P < 0.01). Orphenadrine, but not lidocaine, exhibited longer duration of nociceptive/sensory blockade than that of motor blockade at equipotent doses. Ineffective-dose orphenadrine as adjuvant did not enhance spinal anesthesia with lidocaine. The preclinical data revealed that orphenadrine with a more sensory-selective action over motor block exhibited more potent and longer spinal anesthesia when compared to lidocaine. (C) 2014 Elsevier B.V. All rights reserved. |
| 關聯: | European Journal of Pharmacology, v.742, pp.125-130 |
| 顯示於類別: | [ 食品科技系 ] 期刊論文
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