English  |  正體中文  |  简体中文  |  Items with full text/Total items : 18269/20496 (89%)
Visitors : 10073057      Online Users : 775
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/28608


    標題: Intrathecal orphenadrine elicits spinal block in the rat
    作者: Chen, Yu-Wen
    Tzeng, Jann-Inn
    Chen, Yu-Chung
    Hung, Ching-Hsia
    Wang, Jhi-Joung
    貢獻者: 食品科技系
    關鍵字: Orphenadrine
    Lidocaine
    Spinal anesthesia
    Motor function
    Proptioception
    Nociception
    日期: 2014-11
    上傳時間: 2015-05-06 21:22:22 (UTC+8)
    出版者: Elsevier Science Bv
    摘要: The purpose of this study was to estimate the local anesthetic effect of orphenadrine, an anti-muscarinic agent, in spinal anesthesia and its comparison with the local anesthetic lidocaine. After the rat was injected intrathecally, the spinal block of orphenadrine and lidocaine was constructed in a dosage-dependent fashion. The potency and duration of spinal anesthesia with orphenadrine were compared with that of lidocaine. Our data demonstrated that orphenadrine and lidocaine elicited dose-dependent spinal blockades on the motor function, sensory, and proprioception. On the 50% effective dose (ED50) basis, the ranks of potency in motor function, nociception, and proprioception were orphenadrine > lidocaine (P < 0.01). At equipotent doses (ED25, ED50, ED75), the block duration elicited by orphenadrine was greater than that elicited by lidocaine (P < 0.01). Orphenadrine, but not lidocaine, exhibited longer duration of nociceptive/sensory blockade than that of motor blockade at equipotent doses. Ineffective-dose orphenadrine as adjuvant did not enhance spinal anesthesia with lidocaine. The preclinical data revealed that orphenadrine with a more sensory-selective action over motor block exhibited more potent and longer spinal anesthesia when compared to lidocaine. (C) 2014 Elsevier B.V. All rights reserved.
    關聯: European Journal of Pharmacology, v.742, pp.125-130
    Appears in Collections:[ 食品科技系 ] 期刊論文

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML1850View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback