Intrathecal orphenadrine elicits spinal block in the rat

doi:10.1016/j.ejphar.2014.08.035

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 食品科技系 > 期刊論文 > Item 310902800/28608

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/28608

標題:	Intrathecal orphenadrine elicits spinal block in the rat
作者:	Chen, Yu-Wen Tzeng, Jann-Inn Chen, Yu-Chung Hung, Ching-Hsia Wang, Jhi-Joung
貢獻者:	食品科技系
關鍵字:	Orphenadrine Lidocaine Spinal anesthesia Motor function Proptioception Nociception
日期:	2014-11
上傳時間:	2015-05-06 21:22:22 (UTC+8)
出版者:	Elsevier Science Bv
摘要:	The purpose of this study was to estimate the local anesthetic effect of orphenadrine, an anti-muscarinic agent, in spinal anesthesia and its comparison with the local anesthetic lidocaine. After the rat was injected intrathecally, the spinal block of orphenadrine and lidocaine was constructed in a dosage-dependent fashion. The potency and duration of spinal anesthesia with orphenadrine were compared with that of lidocaine. Our data demonstrated that orphenadrine and lidocaine elicited dose-dependent spinal blockades on the motor function, sensory, and proprioception. On the 50% effective dose (ED50) basis, the ranks of potency in motor function, nociception, and proprioception were orphenadrine > lidocaine (P < 0.01). At equipotent doses (ED25, ED50, ED75), the block duration elicited by orphenadrine was greater than that elicited by lidocaine (P < 0.01). Orphenadrine, but not lidocaine, exhibited longer duration of nociceptive/sensory blockade than that of motor blockade at equipotent doses. Ineffective-dose orphenadrine as adjuvant did not enhance spinal anesthesia with lidocaine. The preclinical data revealed that orphenadrine with a more sensory-selective action over motor block exhibited more potent and longer spinal anesthesia when compared to lidocaine. (C) 2014 Elsevier B.V. All rights reserved.
關聯:	European Journal of Pharmacology, v.742, pp.125-130
Appears in Collections:	[ 食品科技系 ] 期刊論文

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	1850	View/Open

Loading...