Intrathecal orphenadrine elicits spinal block in the rat

doi:10.1016/j.ejphar.2014.08.035

CNU IR > Pharmacy and Science > Dept. of Food Science & Technology > Periodical Articles > Item 310902800/28608

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/28608

Title:	Intrathecal orphenadrine elicits spinal block in the rat
Authors:	Chen, Yu-Wen Tzeng, Jann-Inn Chen, Yu-Chung Hung, Ching-Hsia Wang, Jhi-Joung
Contributors:	食品科技系
Keywords:	Orphenadrine Lidocaine Spinal anesthesia Motor function Proptioception Nociception
Date:	2014-11
Issue Date:	2015-05-06 21:22:22 (UTC+8)
Publisher:	Elsevier Science Bv
Abstract:	The purpose of this study was to estimate the local anesthetic effect of orphenadrine, an anti-muscarinic agent, in spinal anesthesia and its comparison with the local anesthetic lidocaine. After the rat was injected intrathecally, the spinal block of orphenadrine and lidocaine was constructed in a dosage-dependent fashion. The potency and duration of spinal anesthesia with orphenadrine were compared with that of lidocaine. Our data demonstrated that orphenadrine and lidocaine elicited dose-dependent spinal blockades on the motor function, sensory, and proprioception. On the 50% effective dose (ED50) basis, the ranks of potency in motor function, nociception, and proprioception were orphenadrine > lidocaine (P < 0.01). At equipotent doses (ED25, ED50, ED75), the block duration elicited by orphenadrine was greater than that elicited by lidocaine (P < 0.01). Orphenadrine, but not lidocaine, exhibited longer duration of nociceptive/sensory blockade than that of motor blockade at equipotent doses. Ineffective-dose orphenadrine as adjuvant did not enhance spinal anesthesia with lidocaine. The preclinical data revealed that orphenadrine with a more sensory-selective action over motor block exhibited more potent and longer spinal anesthesia when compared to lidocaine. (C) 2014 Elsevier B.V. All rights reserved.
Relation:	European Journal of Pharmacology, v.742, pp.125-130
Appears in Collections:	[Dept. of Food Science & Technology] Periodical Articles

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