Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/28608
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    標題: Intrathecal orphenadrine elicits spinal block in the rat
    作者: Chen, Yu-Wen
    Tzeng, Jann-Inn
    Chen, Yu-Chung
    Hung, Ching-Hsia
    Wang, Jhi-Joung
    貢獻者: 食品科技系
    關鍵字: Orphenadrine
    Lidocaine
    Spinal anesthesia
    Motor function
    Proptioception
    Nociception
    日期: 2014-11
    上傳時間: 2015-05-06 21:22:22 (UTC+8)
    出版者: Elsevier Science Bv
    摘要: The purpose of this study was to estimate the local anesthetic effect of orphenadrine, an anti-muscarinic agent, in spinal anesthesia and its comparison with the local anesthetic lidocaine. After the rat was injected intrathecally, the spinal block of orphenadrine and lidocaine was constructed in a dosage-dependent fashion. The potency and duration of spinal anesthesia with orphenadrine were compared with that of lidocaine. Our data demonstrated that orphenadrine and lidocaine elicited dose-dependent spinal blockades on the motor function, sensory, and proprioception. On the 50% effective dose (ED50) basis, the ranks of potency in motor function, nociception, and proprioception were orphenadrine > lidocaine (P < 0.01). At equipotent doses (ED25, ED50, ED75), the block duration elicited by orphenadrine was greater than that elicited by lidocaine (P < 0.01). Orphenadrine, but not lidocaine, exhibited longer duration of nociceptive/sensory blockade than that of motor blockade at equipotent doses. Ineffective-dose orphenadrine as adjuvant did not enhance spinal anesthesia with lidocaine. The preclinical data revealed that orphenadrine with a more sensory-selective action over motor block exhibited more potent and longer spinal anesthesia when compared to lidocaine. (C) 2014 Elsevier B.V. All rights reserved.
    關聯: European Journal of Pharmacology, v.742, pp.125-130
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